Arresting cancer proliferation by small-molecule gene regulation
about
Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugateDesign and synthesis of a cell-permeable synthetic transcription factor mimic.Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Genome-Targeted Drug Design: Understanding the Netropsin-DNA InteractionDNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instabilityFluorescent probes for nucleic Acid visualization in fixed and live cells.Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation.Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates.Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cellsAlpha-diaminobutyric acid-linked hairpin polyamides.Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dicationCovalent capture: merging covalent and noncovalent synthesis.Synthetic genome readers target clustered binding sites across diverse chromatin states.Expression profiling elucidates a molecular gene signature for pulmonary hypertension in sarcoidosisAn overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.Approaches to target the genome and its epigenome in cancer.Programmable DNA-binding small molecules.Fe(III)-salen and salphen complexes induce caspase activation and apoptosis in human cells.Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound libraryA polarized-light spectroscopy study of interactions of a hairpin polyamide with DNA.Mapping polyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites.Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.Molecular modeling study of checkpoint kinase 1 inhibitors by multiple docking strategies and prime/MM-GBSA calculation.An overview of recent advances in duplex DNA recognition by small molecules.
P2860
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P2860
Arresting cancer proliferation by small-molecule gene regulation
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Arresting cancer proliferation by small-molecule gene regulation
@ast
Arresting cancer proliferation by small-molecule gene regulation
@en
Arresting cancer proliferation by small-molecule gene regulation
@nl
type
label
Arresting cancer proliferation by small-molecule gene regulation
@ast
Arresting cancer proliferation by small-molecule gene regulation
@en
Arresting cancer proliferation by small-molecule gene regulation
@nl
prefLabel
Arresting cancer proliferation by small-molecule gene regulation
@ast
Arresting cancer proliferation by small-molecule gene regulation
@en
Arresting cancer proliferation by small-molecule gene regulation
@nl
P2093
P1476
Arresting cancer proliferation by small-molecule gene regulation
@en
P2093
Benjamin S Edelson
Christian Melander
Joel M Gottesfeld
Liliane A Dickinson
Paramjit S Arora
Ryan Burnett
P304
P356
10.1016/J.CHEMBIOL.2004.09.004
P407
P50
P577
2004-11-01T00:00:00Z