The cyclotides and related macrocyclic peptides as scaffolds in drug design
about
Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineeringGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsThe Cyclic Cystine Ladder in -Defensins Is Important for Structure and Stability, but Not Antibacterial ActivityStructural Insights into the Role of the Cyclic Backbone in a Squash Trypsin InhibitorA population-based evolutionary search approach to the multiple minima problem in de novo protein structure predictionComputational tools for epitope vaccine design and evaluationExpressed protein ligation: a resourceful tool to study protein structure and function.Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions.A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection.Knottin cyclization: impact on structure and dynamics.Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinisCyclotides, a promising molecular scaffold for peptide-based therapeutics.Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptorsIdentification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides.In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin.Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae)Neutrophil elastase inhibitors.Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin.Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401.Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar caneFunctional Analysis of Genes Involved in the Biosynthesis of Enterocin NKR-5-3B, a Novel Circular Bacteriocin.Host-defense activities of cyclotides.Cyclotides, a novel ultrastable polypeptide scaffold for drug discoveryApproaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffoldingUterotonic plants and their bioactive constituentsKNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007Unfolding the fold of cyclic cysteine-rich peptides.Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactionsExpression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions.MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myelomaCellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.Computational analysis of the MCoTI-II plant defence knottin reveals a novel intermediate conformation that facilitates trypsin binding.Asn347 Glycosylation of Corticosteroid-binding Globulin Fine-tunes the Host Immune Response by Modulating Proteolysis by Pseudomonas aeruginosa and Neutrophil Elastase.Peptide bicycles that inhibit the Grb2 SH2 domain.Discovery of cyclotide-like protein sequences in graminaceous crop plants: ancestral precursors of circular proteins?Insights into the molecular flexibility of θ-defensins by NMR relaxation analysis.Distribution and evolution of circular miniproteins in flowering plants
P2860
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P2860
The cyclotides and related macrocyclic peptides as scaffolds in drug design
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2006 nî lūn-bûn
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2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@ast
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@en
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@nl
type
label
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@ast
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@en
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@nl
prefLabel
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@ast
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@en
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@nl
P2093
P1476
The cyclotides and related macrocyclic peptides as scaffolds in drug design
@en
P2093
David J Craik
Masa Cemazar
Norelle L Daly
P304
P407
P577
2006-03-01T00:00:00Z