Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
about
Recent Advances Toward the Discovery of Drug-Like Peptides De novoIn Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered CyclotideSemienzymatic Cyclization of Disulfide-rich Peptides Using Sortase AAntimicrobial Peptides from PlantsPhosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions.Intein applications: from protein purification and labeling to metabolic control methods.Polycyclic peptide therapeutics.Dynamic scenario of membrane binding process of kalata b1Recombinant expression of backbone-cyclized polypeptides.Amino group binding peptide aptamers with double disulphide-bridged loops selected by in vitro selection using cDNA display.Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactionsRapid parallel synthesis of bioactive folded cyclotides by using a tea-bag approach.PredSTP: a highly accurate SVM based model to predict sequential cystine stabilized peptides.Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3Combinatorial chemistry in drug discovery.Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactionsNatural antimicrobial peptides as promising anti-HIV candidates.Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity.Disulfide Bridges: Bringing Together Frustrated Structure in a Bioactive Peptide.Expression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions.Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis.Cyclotides as grafting frameworks for protein engineering and drug design applications.Cystine-knot peptides: emerging tools for cancer imaging and therapy.Natural products with antischistosomal activity.Plant cystine-knot peptides: pharmacological perspectives.Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.Cyclotides: Overview and Biotechnological Applications.In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent.Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations.The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites.Plant antimicrobial peptides snakin-1 and snakin-2: chemical synthesis and insights into the disulfide connectivity.Recombinant Expression of Cyclotides Using Split Inteins.Structural basis of ribosomal peptide macrocyclization in plants.Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation.Single-step purification of cyclotides using affinity chromatography.Screening, large-scale production and structure-based classification of cystine-dense peptides.Structural analyses of Arabidopsis thaliana legumain γ reveal the differential recognition and processing of proteolysis and ligation substrates.
P2860
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P2860
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
@ast
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
@en
type
label
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
@ast
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
@en
prefLabel
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
@ast
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
@en
P2093
P2860
P1476
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
@en
P2093
Andrew Gould
Julio A Camarero
Teshome L Aboye
P2860
P304
P356
10.2174/138161211798999438
P577
2011-12-01T00:00:00Z