Exploring biologically relevant chemical space with metal complexes
about
Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitorStructure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and SelectivityExtremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3βStructurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase InhibitorsThe structure of metallo-DNA with consecutive thymine-HgII-thymine base pairs explains positive entropy for the metallo base pair formationContributions of academic laboratories to the discovery and development of chemical biology toolsA Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands.FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions.Synthesis of rhenium-centric reverse turn mimics.Organometallic anticancer compoundsBalancing novelty with confined chemical space in modern drug discovery.Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex ProbesA flexible-protein molecular docking study of the binding of ruthenium complex compounds to PIM1, GSK-3β, and CDK2/Cyclin A protein kinases.Application of metal coordination chemistry to explore and manipulate cell biology.Developing an anticancer copper(II) pro-drug based on the nature of cancer cell and human serum albumin carrier IIA subdomain: mouse model of breast cancer.From conventional to unusual enzyme inhibitor scaffolds: the quest for target specificity.Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium's success?Organometallic compounds: an opportunity for chemical biology?Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes.Metal complex interactions with DNA.Antiangiogenic and Toxic Effects of Genistein, Usnic Acid, and Their Copper Complexes in Zebrafish Embryos at Different Developmental Stages.Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells.Effects of the ruthenium-based drug NAMI-A on the roles played by TGF-β1 in the metastatic process.Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands.Peptide Bioconjugates of Electron-Poor Metallocenes: Synthesis, Characterization, and Anti-Proliferative Activity.Mitochondria are the primary target in the induction of apoptosis by chiral ruthenium(II) polypyridyl complexes in cancer cells.Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity.The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(II) asymmetric complexes.The [(Cp)M(CO)(3)] (M=Re, (99m)Tc) building block for imaging agents and bioinorganic probes: perspectives and limitations.Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor.On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging.The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials.Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes.A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition.Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor.Histone-deacetylase-targeted fluorescent ruthenium(II) polypyridyl complexes as potent anticancer agents.Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation.Designing new iridium(iii) arene complexes of naphthoquinone derivatives as anticancer agents: a structure-activity relationship study.
P2860
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P2860
Exploring biologically relevant chemical space with metal complexes
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Exploring biologically relevant chemical space with metal complexes
@ast
Exploring biologically relevant chemical space with metal complexes
@en
Exploring biologically relevant chemical space with metal complexes
@nl
type
label
Exploring biologically relevant chemical space with metal complexes
@ast
Exploring biologically relevant chemical space with metal complexes
@en
Exploring biologically relevant chemical space with metal complexes
@nl
prefLabel
Exploring biologically relevant chemical space with metal complexes
@ast
Exploring biologically relevant chemical space with metal complexes
@en
Exploring biologically relevant chemical space with metal complexes
@nl
P3181
P1476
Exploring biologically relevant chemical space with metal complexes
@en
P304
P3181
P356
10.1016/J.CBPA.2007.05.013
P407
P50
P577
2007-06-01T00:00:00Z