The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7
about
Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosisGrowth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongationA liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approachesThe blood-testis barrier and its implications for male contraceptionJNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis.Protective effects and functional mechanisms of Lactobacillus gasseri SBT2055 against oxidative stress.Anthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling networkHyperthermia differently affects connexin43 expression and gap junction permeability in skeletal myoblasts and HeLa cells.EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activationC-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis mediaIdentification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms.MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.Virtual screening of chemical compounds active against breast cancer cell lines based on cell cycle modelling, prediction of cytotoxicity and interaction with targets.Thioredoxin Activates MKK4-NFκB Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells.Protection of rat intestinal epithelial cells from ischemia/reperfusion injury by (D-Ala2, D-Leu5)-enkephalin through inhibition of the MKK7-JNK signaling pathway.Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus SecretionTRAF1 is a key mediator for hepatic ischemia/reperfusion injuryEndothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium.Alpinetin suppresses proliferation of human hepatoma cells by the activation of MKK7 and elevates sensitization to cis-diammined dichloridoplatium.Restoring KLF5 in esophageal squamous cell cancer cells activates the JNK pathway leading to apoptosis and reduced cell survival.Functional p38 MAPK identified by biomarker profiling of pancreatic cancer restrains growth through JNK inhibition and correlates with improved survival.JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinasesBRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding.JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention.c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons.JNK inhibitors as anti-inflammatory and neuroprotective agents.Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer.Altered TGF-α/β signaling drives cooperation between breast cancer cell populations.Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of MKK4/JNK via NF-κB mediated urokinase plasminogen activator expression.Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.Novel tumor-suppressor function of KLF4 in pediatric T-cell acute lymphoblastic leukemia.Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK.Tetramethyl Pyrazine Protects Hippocampal Neurons Against Anoxia/Reoxygenation Injury Through Inhibiting Apoptosis Mediated by JNK/MARK Signal Pathway.The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila.Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins.Isoform-specific palmitoylation of JNK regulates axonal development.
P2860
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P2860
The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@ast
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@en
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@nl
type
label
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@ast
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@en
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@nl
prefLabel
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@ast
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@en
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@nl
P2093
P1476
The bottleneck of JNK signalin ...... aracteristics of MKK4 and MKK7
@en
P2093
Thomas Herdegen
Vicki Waetzig
Wiebke Haeusgen
P304
P356
10.1016/J.EJCB.2010.11.008
P407
P577
2011-01-01T00:00:00Z