BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling. - Test2 - elhamkhani - TriplyDB

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

http://www.wikidata.org/entity/Q37271732

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Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia.Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy.Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.Mechanism and consequences of RAF kinase activation by small-molecule inhibitors BRAF inhibitors: experience in thyroid cancer and general review of toxicity.Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition.Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor.Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.BRAF signals to pro-apoptotic BIM to enhance AraC cytotoxicity induced in AML cells by Vitamin D-based differentiation agents.Dual c-Jun N-terminal kinase-cyclin D1 and extracellular signal-related kinase-c-Jun disjunction in human melanoma.Comparative profiles of BRAF inhibitors: the paradox index as a predictor of clinical toxicity Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma.Vemurafenib Limits Influenza A Virus Propagation by Targeting Multiple Signaling Pathways.Reduced risk of apoptosis: mechanisms of stress responses.In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease

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P2860

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

http://www.wikidata.org/entity/Q37271732

description

2013 nî lūn-bûn

@nan

2013年の論文

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2013年学术文章

@wuu

2013年学术文章

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2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

@yue

2013年學術文章

@zh

2013年學術文章

@zh-hant

name

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

@en

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

@nl

type

label

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

@en

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

@nl

prefLabel

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

@en

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

@nl

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BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

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Ana M Ciurea

http://www.w3.org/2001/XMLSchema#string

Charles H Adelmann

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David W Dwyer

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Deepavali Chakravarti

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Elsa R Flores

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Grace Ching

http://www.w3.org/2001/XMLSchema#string

Harina Vin

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Jonathan L Curry

http://www.w3.org/2001/XMLSchema#string

Karin Ehrenreiter

http://www.w3.org/2001/XMLSchema#string

Kenneth Y Tsai

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P2860

Molecular cloning and characterization of a novel member of the MAP kinase superfamily

Hallmarks of Cancer: The Next Generation

Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif

MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

A gene atlas of the mouse and human protein-encoding transcriptomes

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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e00969

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10.7554/ELIFE.00969

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2

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Manuela Baccarini

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2013-11-05T00:00:00Z

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258313470

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apoptotic process

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3814616

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