Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells - Test2 - elhamkhani - TriplyDB

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

http://www.wikidata.org/entity/Q28308084

about

Gaucher disease and comorbidities: B-cell malignancy and parkinsonism Glucocerebrosidase and Parkinson disease: Recent advances Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease The relationship between glucocerebrosidase mutations and Parkinson disease A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments Atypical juvenile presentation of GM2 gangliosidosis AB in a patient compound-heterozygote for c.259G > T and c.164C > T mutations in the GM2A gene.Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate.Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies.Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.Gaucher-Associated Parkinsonism.Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations Applications of iPSC-derived models of Gaucher disease [More than expectorant: new scientific data on ambroxol in the context of the treatment of bronchopulmonary diseases].ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.A Personalized Approach to Parkinson's Disease Patients Based on Founder Mutation Analysis A new glucocerebrosidase-deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease.Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts.Basic science breaks through: New therapeutic advances in Parkinson's disease.GBA mutations in Parkinson disease: earlier death but similar neuropathological features.Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectives.Glucocerebrosidase in Parkinson's disease: Insights into pathogenesis and prospects for treatment.New Directions in Gaucher Disease.Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease.Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies.Non-motor features of Parkinson disease.Glucocerebrosidase Mutations in Parkinson Disease.Survival and dementia in GBA-associated Parkinson's disease: The mutation matters.Cognitive and motor functioning in elderly glucocerebrosidase mutation carriers.Glucocerebrosidase enzyme activity in GBA mutation Parkinson's disease Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells.Ambroxol for the treatment of fibromyalgia: science or fiction?Chaperone-Based Therapies for Disease Modification in Parkinson's Disease.Enzyme enhancers for the treatment of Fabry and Pompe disease.

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P2860

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

http://www.wikidata.org/entity/Q28308084

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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type

label

Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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prefLabel

Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Ambroxol improves lysosomal bi ...... linked Parkinson disease cells

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Alisdair McNeill

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Anthony H V Schapira

http://www.w3.org/2001/XMLSchema#string

Atul Mehta

http://www.w3.org/2001/XMLSchema#string

J Mark Cooper

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Tom Foltynie

http://www.w3.org/2001/XMLSchema#string

P2860

Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

The genetics and neuropathology of Parkinson's disease

Protein degradation pathways in Parkinson's disease: curse or blessing

Chaperone-mediated autophagy markers in Parkinson disease brains

Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts

The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease

Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome

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1481-1495

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scholarly article

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1484516

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10.1093/BRAIN/AWU020

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P433

Pt 5

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P478

137

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Andrey Y Abramov

Derralynn A Hughes

Joana Magalhaes

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2014-05-01T00:00:00Z

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260396479

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24574503

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Parkinson's disease

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3999713

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