Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds - Test2 - elhamkhani - TriplyDB

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

http://www.wikidata.org/entity/Q28314993

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Mitochondria Initiate and Regulate Sarcopenia Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics.Meat Intake and the Dose of Vitamin B3 - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.Adipose tissue NAD+ biology in obesity and insulin resistance: From mechanism to therapy Physiological links of circadian clock and biological clock of aging.A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study.Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma.Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing.Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application.Mediterranean diet and inflammaging within the hormesis paradigm.CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB.Key proteins and pathways that regulate lifespan.Sirtuins, a promising target in slowing down the ageing process.SIRT6: Novel Mechanisms and Links to Aging and Disease.Could Sirtuin Activities Modify ALS Onset and Progression?Mitophagy in neurodegeneration and aging.Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy.Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.Aging, Metabolism, and Cancer Development: from Peto's Paradox to the Warburg Effect.Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae.Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals.Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin.Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet?The landscape of transcription errors in eukaryotic cells.Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study.SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation.Mitochondrial matrix pH as a decisive factor in neurometabolic imaging.Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.Metabolic pathways at the crossroads of diabetes and inborn errors.Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells.Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™).NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.Breaking the Ceiling of Human Maximal Lifespan.

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

http://www.wikidata.org/entity/Q28314993

description

2016 nî lūn-bûn

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2016 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2016 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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name

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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type

label

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

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Nature Reviews Molecular Cell Biology

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Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

@en

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David A Sinclair

http://www.w3.org/2001/XMLSchema#string

Michael S Bonkowski

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P2860

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

SIRT1 negatively regulates the mammalian target of rapamycin

Sir2-independent life span extension by calorie restriction in yeast

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

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679-690

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scholarly article

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10.1038/NRM.2016.93

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11

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1038682840

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27552971

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5107309

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