about
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombinationThe RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damageRNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsThe cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaksXrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IVOrchestration of the DNA-damage response by the RNF8 ubiquitin ligaseStructural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitorsAtomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular MachineAn allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzymeA Strategy for Modulation of Enzymes in the Ubiquitin SystemOTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme FunctionReconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme systemStructural basis of Rad53 kinase activation by dimerization and activation segment exchangeStructural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesisThe structural basis of modified nucleosome recognition by 53BP1Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryCcr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.HELB Is a Feedback Inhibitor of DNA End ResectionPP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpointA viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responsesThe RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombinationThe FHA domain is a modular phosphopeptide recognition motif.CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptationRnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndromeA siRNA-based screen for genes involved in chromosome end protection.The FHA domain.DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?Regulation of DNA damage responses by ubiquitin and SUMO.Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Daniel Durocher
@ast
Daniel Durocher
@en
Daniel Durocher
@es
Daniel Durocher
@nl
Daniel Durocher
@sl
type
label
Daniel Durocher
@ast
Daniel Durocher
@en
Daniel Durocher
@es
Daniel Durocher
@nl
Daniel Durocher
@sl
prefLabel
Daniel Durocher
@ast
Daniel Durocher
@en
Daniel Durocher
@es
Daniel Durocher
@nl
Daniel Durocher
@sl
P1053
A-7733-2010
P106
P1153
7003395294
P21
P31
P3829
P496
0000-0003-3863-8635