Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization
about
tRNAs as antibiotic targetsTargeting Antibiotic ResistanceThe potential for emerging therapeutic options for Clostridium difficile infectionIn vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A)Constraining cyclic peptides to mimic protein structure motifs.Two heterologously expressed Planobispora rosea proteins cooperatively induce Streptomyces lividans thiostrepton uptake and storage from the extracellular mediumManipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation.Multicenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infections.Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon ActinomyceteMechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571Recent advances in the chemistry and biology of naturally occurring antibiotics.Thiopeptide engineering: a multidisciplinary effort towards future drugs.Growing the seeds sown by Piero Sensi.Elfamycins: inhibitors of elongation factor-Tu.Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571.YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.The unique tuf2 gene from the kirromycin producer Streptomyces ramocissimus encodes a minor and kirromycin-sensitive elongation factor Tu.In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.Differential susceptibilities of enterococcal species to elfamycin antibiotics.Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.Sponge-derived Kocuria and Micrococcus spp. as sources of the new thiazolyl peptide antibiotic kocurin.Efficacy of LFF571 in a hamster model of Clostridium difficile infection.Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycinElongation factor Tu3 (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus Is resistant to three classes of EF-Tu-specific inhibitors.Pyridinyl polythiazole class peptide antibiotic micrococcin P1, secreted by foodborne Staphylococcus equorum WS2733, is biosynthesized nonribosomally.Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A.Antibiotic production improvement in the rare actinomycete Planobispora rosea by selection of mutants resistant to the aminoglycosides streptomycin and gentamycin and to rifamycin.An elongation factor Tu (EF-Tu) resistant to the EF-Tu inhibitor GE2270 in the producing organism Planobispora rosea.Decrease in the levels of NGF and BDNF in brains of mice fed a tryptophan-deficient diet.Total synthesis of antibiotics GE2270A and GE2270T.Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression.From 2,6-Dichloronicotinic Acid to Thiopeptide CoresThe Negishi Cross-Coupling in the Synthesis of Natural Products and Bioactive Molecules
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P2860
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization
description
1991 nî lūn-bûn
@nan
1991 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@ast
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@en
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@nl
type
label
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@ast
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@en
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@nl
prefLabel
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@ast
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@en
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@nl
P2093
P3181
P1476
Antibiotic GE2270 a: a novel i ...... Isolation and characterization
@en
P2093
B P Goldstein
F Ripamonti
G S Saddler
L Gastaldo
N Montanini
R Lorenzetti
P304
P3181
P356
10.7164/ANTIBIOTICS.44.693
P407
P577
1991-07-01T00:00:00Z