Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571
about
Thiopeptide antibiotics: retrospective and recent advancesMulticenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infections.Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.A first-in-human, randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study to assess the safety and tolerability of LFF571 in healthy volunteers.Therapy of Clostridium difficile infection: perspectives on a changing paradigm.Thiopeptide engineering: a multidisciplinary effort towards future drugs.Natural product and natural product derived drugs in clinical trials.Natural products as probes in pharmaceutical research.Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571.YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.New antibiotics in clinical trials for Clostridium difficile.Subinhibitory concentrations of LFF571 reduce toxin production by Clostridium difficile.Antimicrobial activity of LFF571 and three treatment agents against Clostridium difficile isolates collected for a pan-European survey in 2008: clinical and therapeutic implications.Efficacy of LFF571 in a hamster model of Clostridium difficile infection.Characterization of a novel plasmid-borne thiopeptide gene cluster in Staphylococcus epidermidis strain 115.In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.Advances in the diagnosis and treatment of Clostridium difficile infections.Total Synthesis of the Posttranslationally Modified Polyazole Peptide Antibiotic Plantazolicin A.Novel Antimicrobials for the Treatment of Clostridium difficile Infection.
P2860
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P2860
Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Mechanism of action of and mec ...... dium difficile compound LFF571
@ast
Mechanism of action of and mec ...... dium difficile compound LFF571
@en
type
label
Mechanism of action of and mec ...... dium difficile compound LFF571
@ast
Mechanism of action of and mec ...... dium difficile compound LFF571
@en
prefLabel
Mechanism of action of and mec ...... dium difficile compound LFF571
@ast
Mechanism of action of and mec ...... dium difficile compound LFF571
@en
P2093
P2860
P356
P1476
Mechanism of action of and mec ...... dium difficile compound LFF571
@en
P2093
J Dzink-Fox
M J Lamarche
M Sachdeva
P2860
P304
P356
10.1128/AAC.06354-11
P407
P577
2012-05-29T00:00:00Z