Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis
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Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugsPlatensimycin activity against mycobacterial beta-ketoacyl-ACP synthasesEffects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistanceBiosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferaseMycobacterium tuberculosis proteins involved in mycolic acid synthesis and transport localize dynamically to the old growing pole and septumCrystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase IIINew Insight into the Mechanism of Action of and Resistance to Isoniazid: Interaction of Mycobacterium tuberculosis enoyl-ACP Reductase with INH-NADPA Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosisIsonicotinic Acid Hydrazide Conversion to Isonicotinyl-NAD by Catalase-peroxidasesN-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular ActivityCellular impermeability and uptake of biocides and antibiotics in Gram-positive bacteria and mycobacteriaPathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosisThe molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosisThe missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosisIdentification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosisSignature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosisEvidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis.Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core.Chemical validation of molecular mimicry: interaction of cholera toxin with Campylobacter lipooligosaccharides.Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.Trafficking pathways of mycolic acids: structures, origin, mechanism of formation, and storage form of mycobacteric acids.Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme.Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.Targeting tuberculosis through a small focused library of 1,2,3-triazoles.Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids.Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival.Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosisMycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species.Emerging therapeutic targets in tuberculosis: post-genomic era.Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis.Analysis of novel mycobacteriophages indicates the existence of different strategies for phage inheritance in mycobacteria.Current status and future development of antitubercular chemotherapy.A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organismsFatty acid biosynthesis as a target for novel antibacterialsComparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivationComputer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles.Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG
P2860
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P2860
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@ast
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@en
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@nl
type
label
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@ast
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@en
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@nl
prefLabel
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@ast
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@en
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@nl
P2093
P2860
P1476
Inactivation of the inhA-encod ...... sis of Mycobacterium smegmatis
@en
P2093
C Vilchèze
H R Morbidoni
J C Sacchettini
T R Weisbrod
W R Jacobs
P2860
P304
P356
10.1128/JB.182.14.4059-4067.2000
P407
P577
2000-07-01T00:00:00Z