Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes - Test2 - elhamkhani - TriplyDB

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

http://www.wikidata.org/entity/Q28344700

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Endocrine regulation of energy metabolism by the skeleton A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase Farnesoid X receptor is essential for normal glucose homeostasis Pim3 negatively regulates glucose-stimulated insulin secretion Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight.Biological effects of growth hormone on carbohydrate and lipid metabolism.Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients.Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K Molecular mechanisms of insulin resistance in type 2 diabetes mellitus Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome Differential effects of exposure to maternal obesity or maternal weight loss during the periconceptional period in the sheep on insulin signalling molecules in skeletal muscle of the offspring at 4 months of age.Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes.The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.

P2860

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P2860

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

http://www.wikidata.org/entity/Q28344700

description

2002 nî lūn-bûn

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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2002 թվականի հունվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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Reduced expression of the muri ...... aling and ameliorates diabetes

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Reduced expression of the muri ...... aling and ameliorates diabetes

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Reduced expression of the muri ...... aling and ameliorates diabetes

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Reduced expression of the muri ...... aling and ameliorates diabetes

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Journal of Clinical Investigation

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Reduced expression of the muri ...... aling and ameliorates diabetes

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David A Fruman

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Franck Mauvais-Jarvis

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Kei Sakamoto

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Laurie J Goodyear

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Lewis C Cantley

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Matteo Iannacone

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Michael F Hirshman

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P2860

Positional cloning of the mouse obese gene and its human homologue

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.

Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.

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10.1172/JCI0213305

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1

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Domenico Accili

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