Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
about
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsMultidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapyWhy are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domainsCrystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant VariantsStructural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceThe renaissance of fixed dose combinations: CombivirAntiviral activity of CYC202 in HIV-1-infected cellsA new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidineMechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variantsAntiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv miceSelection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidineDrug Resistance and Virological Failure among HIV-Infected Patients after a Decade of Antiretroviral Treatment Expansion in Eight Provinces of ChinaInfluence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosidesSusceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitorsNovel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell culture5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profileIn vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl proteaseThe M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2'-deoxy-3'-thiacytidine and a reduced ability to synthesize viral DNAPatterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor lovirideAnti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitroGenetic variation and susceptibilities to protease inhibitors among subtype B and F isolates in BrazilIntramuscular hepatitis B immune globulin combined with lamivudine for prophylaxis against hepatitis B recurrence after liver transplantationSelective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile an1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activityCombination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89The antiretrovirus drug 3'-azido-3'-deoxythymidine increases the retrovirus mutation rateSignificance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibilityIn vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosineEvaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replicationIdentification of BMS-200475 as a potent and selective inhibitor of hepatitis B virusThe nucleoside analog-resistant E89G mutant of human immunodeficiency virus type 1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitorsNovel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitroAn in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activityA novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2',3'-dideoxy-3'-thiacytidineN348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistanceOnly slight impact of predicted replicative capacity for therapy response predictionA synthetic HIV-1 subtype C backbone generates comparable PR and RT resistance profiles to a subtype B backbone in a recombinant virus assay
P2860
Q24682078-A834764B-15CD-4BEB-AED4-A7EB58E74578Q24684152-E873EF29-D0F9-4E0E-BAD6-A35F06DE23EDQ27487167-964D1B8A-33A5-4329-87C9-0D306EE9410CQ27498357-104AC35E-06BA-45B7-91F3-19F660E35E7CQ27639579-56838132-2D94-45CE-A705-828917CCBCB9Q27650325-6D60241F-B134-4424-975E-199931417FB6Q27657718-78BAC285-D132-491C-890F-AECA4DFBB6D7Q28279752-1AD16D3C-4E2A-42EA-845E-4A1C88CAF293Q28292152-687CD3A5-8C89-41C4-B38E-96EE3D899ADDQ28343476-0F1397E0-F115-469C-B86C-91AD983D492EQ28343606-795D660A-1911-4A13-BDA0-AD945B5798E0Q28343930-6A187D59-2E80-48A5-BD1E-CA394D052B18Q28344137-B2E00DB2-0A22-450D-8269-6F205C7A309BQ28354095-07862847-460B-49D0-BE73-B94BD06CD5BAQ28367580-5FE616B1-12C6-4F7A-A36C-7C2130F72180Q28367590-B56B14EA-1E95-4B21-BB86-4095089251A7Q28367594-10D7F949-B15F-4FDA-A523-D6579D846E90Q28367605-7D7D3247-0227-4196-824A-874186A01914Q28367941-5275F55E-F11E-40FA-8854-07994B4635BAQ28368336-1B2BFEC4-D92A-41DF-B5EB-F8614A01B247Q28369293-E3CD5BB9-D7D0-49F5-B945-11F884E95922Q28369464-05214EC3-1AD4-4B38-BFB4-7BA23A864E32Q28369565-E3CA62A2-547B-42D5-AC9A-6D38AF81F661Q28375636-433F48AD-065D-491B-94BF-2ED417FF6574Q28378760-CBFD3D30-01AA-47F8-8D95-946846C60B07Q28378894-C6571180-959B-4351-9FC7-C9B6FDE2CCF3Q28378896-852E80F7-4E0D-4480-B5E9-9AB34345EA83Q28378929-84643BD3-E4EB-43B4-93AE-3330E38A35AFQ28378951-A390B751-562D-47A4-BB49-65894CD9DE94Q28378965-E06E626E-EB3E-460C-9AF6-D494A2C34414Q28378991-3CF4B0B0-A790-4244-AF73-0EB5DC532CD6Q28379014-624C1DF4-AA38-4134-9305-06BE03C85A0CQ28379139-0723564E-2FAC-4CE5-AB87-FD29A2663BC0Q28379249-0F8FABCE-91FE-450F-951B-6A22023FE1C3Q28379270-6BA3C81C-6AE3-4D9D-A41A-7E307C32316EQ28379406-917296B8-448A-4E91-88A6-B5CA95A26DEDQ28379499-70F43B5C-F8DA-434A-853B-B7E84C3A7499Q28471689-EFC6EEE1-639A-40AE-B294-ADDD47963638Q28472749-932E6F5D-C5F5-4E6A-8038-274AC8551CC9Q28478253-A08FFCA8-86F5-4D37-99EA-E89994D006B0
P2860
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@ast
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@en
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@nl
type
label
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@ast
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@en
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@nl
prefLabel
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@ast
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@en
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@nl
P2093
P2860
P356
P1476
Rapid in vitro selection of hu ...... egion of reverse transcriptase
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.12.5653
P407
P577
1993-06-15T00:00:00Z