Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists - Test2 - elhamkhani - TriplyDB

Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists

Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists

http://www.wikidata.org/entity/Q28368377

about

Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.Ribose modified nucleosides and nucleotides as ligands for purine receptors Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors Pyran Template Approach to the Design of Novel A3 Adenosine Receptor Antagonists Targeted deletion of A(3) adenosine receptors improves tolerance to ischemia-reperfusion injury in mouse myocardium.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.Adenosine and ischemic preconditioning.Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats.Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain Medicinal chemistry of adenosine, P2Y and P2X receptors.Controlling murine and rat chronic pain through A3 adenosine receptor activation Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygen-glucose deprivation episodes of different duration.Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.Functionalized congeners of 1,4-dihydropyridines as antagonist molecular probes for A3 adenosine receptors Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase Cε.p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA.Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1)Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells.The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.Purinergic A2b Receptor Activation by Extracellular Cues Affects Positioning of the Centrosome and Nucleus and Causes Reduced Cell Migration.Putative role of the adenosine A(3) receptor in the antiproliferative action of N (6)-(2-isopentenyl)adenosine.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells.Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro.Design and synthesis of new 1,4-dihydropyridines containing 4(5)-chloro-5(4)-imidazolyl substituent as a novel calcium channel blocker.The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells.Organoruthenium antagonists of human A₃ adenosine receptors.

P2860

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P2860

Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists

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description

1998 nî lūn-bûn

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1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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1998 թվականի օգոստոսին հրատարակված գիտական հոդված

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N Melman

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P2860

Molecular cloning and characterization of the human A3 adenosine receptor.

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor

Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists

Pharmacological characterization of novel A3 adenosine receptor-selective antagonists

Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus.

Adenosine A3 receptors: novel ligands and paradoxical effects.

Adenosine A3 receptor stimulation and cerebral ischemia

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor

Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors.

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