Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction - Test2 - elhamkhani - TriplyDB

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

http://www.wikidata.org/entity/Q28378871

about

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo Rapamycin and mTOR kinase inhibitors The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal Cancer DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Ten things you should know about protein kinases: IUPHAR Review 14 Is Wortmannin-Induced Reorganization of the trans-Golgi Network the Key to Explain Charasome Formation?Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae.Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin Adipose tissue dysfunction and its effects on tumor metabolism Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2 Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action PI3K/PTEN signaling in angiogenesis and tumorigenesis Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions PI3K pathway alterations in cancer: variations on a theme Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase.Unsupervised explorative data analysis of normal human leukocytes and BCR/ABL positive leukemic cells mid-infrared spectra.Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription.Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo.Modulation of cellular apoptotic potential: contributions to oncogenesis.Control of autophagy with small molecules.

P2860

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P2860

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

http://www.wikidata.org/entity/Q28378871

description

1996 nî lūn-bûn

@nan

1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

@zh-mo

1996年論文

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1996年论文

@wuu

name

Wortmannin inactivates phospho ...... he phosphate transfer reaction

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Wortmannin inactivates phospho ...... he phosphate transfer reaction

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Wortmannin inactivates phospho ...... he phosphate transfer reaction

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type

label

Wortmannin inactivates phospho ...... he phosphate transfer reaction

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Wortmannin inactivates phospho ...... he phosphate transfer reaction

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Wortmannin inactivates phospho ...... he phosphate transfer reaction

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prefLabel

Wortmannin inactivates phospho ...... he phosphate transfer reaction

@ast

Wortmannin inactivates phospho ...... he phosphate transfer reaction

@en

Wortmannin inactivates phospho ...... he phosphate transfer reaction

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Molecular and Cellular Biology

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Wortmannin inactivates phospho ...... he phosphate transfer reaction

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B Vanhaesebroeck

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G Bulgarelli-Leva

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G Panayotou

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L Pirola

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M D Waterfield

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M J Zvelebil

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M P Wymann

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P2860

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

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scholarly article

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1065774

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10.1128/MCB.16.4.1722

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4

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16

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1996-04-01T00:00:00Z

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8657148

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231159

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