Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.
about
Ku recruits XLF to DNA double-strand breaksFunctional and biochemical dissection of the structure-specific nuclease ARTEMISThe leucine rich region of DNA-PKcs contributes to its innate DNA affinity.Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.Phosphorylation of Artemis following irradiation-induced DNA damage.The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosisRole of non-homologous end joining in V(D)J recombinationIdentification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol AFunctional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombinationAutophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks.Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)Non-homologous end joining: emerging themes and unanswered questions.DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease?A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.Profiling global kinome signatures of the radioresistant MCF-7/C6 breast cancer cells using MRM-based targeted proteomicsChoosing the right path: does DNA-PK help make the decision?Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK.Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.Regulation of DNA repair by S-nitrosylation.Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombinationThe DNA-dependent protein kinase: the director at the end.N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.The life and death of DNA-PK.Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathwayRestoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease.Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1.PRKDC mutations in a SCID patient with profound neurological abnormalities.Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends.trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining.The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage.The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain.Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice.Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.Cryo-EM structure of human DNA-PK holoenzyme.DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
P2860
Q24302301-131AF0C4-C9CC-4D60-A805-9619334B8FC6Q24564574-E6D47E55-7E6F-4A31-9542-62455138B2BCQ24810597-F5A7D330-572F-49B4-AB1D-CDB5F70A911DQ27919628-8DC70B2B-7CED-45A5-A12F-61A12A92907CQ27919641-9722395D-DAFD-4180-827C-70DC6ECC31E0Q27919664-962DE940-5475-499A-A5B2-1CFC9938DB4FQ28081821-2C8FD4AF-B70F-4812-A407-21F8396AB38FQ28266265-3A8B8D6D-B459-487E-95C2-3107E3F90D91Q28485497-A3F9550B-94C3-42FA-9DFC-289DB498E076Q28508673-4DC33EA9-59A7-4812-AE68-56639AB50E80Q33282240-73C75990-9730-44D2-8C66-19A734F8AD64Q33818265-0644060C-7781-4610-83B7-3CFC37B3978CQ33854272-951D24B2-F546-418D-A5B7-DBD06ACC9C60Q33892330-E9D197FC-B768-407A-A28F-8C370738ACD7Q34396025-DB7E68D5-2243-4024-846F-10C409DE1DE5Q34855520-26A09C72-DA67-44D1-A48A-A2B199578DD1Q35029335-BE00FFC9-A3F0-431E-8675-B69F5FD35CBFQ35074435-113EBA09-2062-490D-A350-ACD2295B5C2CQ35077127-E35645E2-AD85-4800-84C8-EB61D1441D1AQ35206885-A8389452-605D-4516-9FE8-0B4E9211AC6AQ35637089-2CCE5E9C-441B-441A-9B23-DDA9F5687E5FQ35669767-FAE628F5-4329-426A-A227-0ED59D4C67EDQ35830413-6890D764-EBCA-49A5-994B-7FB73F524660Q35888831-97AFB6B9-3039-4F26-99EE-799729928620Q35980970-CA49C234-8CE7-4AEE-83ED-1A9E52570C7AQ36089263-39B6EEF5-81D7-4B16-AF98-5EF18535F22AQ36706287-A728BE74-3D75-4818-B903-8500F7322C4EQ36998015-79E23677-7B68-4404-8DD0-563393BEBC95Q37365625-D563A367-60B7-493D-8296-D19040492CEDQ37474844-6C803515-356D-4F07-8048-D3849182D9BAQ38955848-93BB13AF-99AD-4D99-A117-9877184203D0Q39946274-D8EECD8C-4FC9-4382-92C2-E742D67030B3Q40160195-440714E3-E3C2-47D9-8DF9-28728306D165Q40195606-2A534F2A-E744-49BC-AE1B-78E1D2764F4BQ40198361-8827E5A4-CB5B-4524-9A6B-D0E90E36980DQ40603571-8C788000-26CC-4A1E-B897-315F94DCC99AQ40701520-F23B52C3-40FB-4DBE-B30F-BBF4B4EF9FFEQ41126460-BA1DAC8B-4D9F-48A1-89A9-842388ED4BD3Q41596688-54231443-4F49-49D5-AA8D-8717C2B758DDQ42159418-1F2A5523-3148-45FC-BF79-9C5DFCDBFD7C
P2860
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.
description
2000 nî lūn-bûn
@nan
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Both V(D)J recombination and r ...... ffice for V(D)J recombination.
@ast
Both V(D)J recombination and r ...... ffice for V(D)J recombination.
@en
type
label
Both V(D)J recombination and r ...... ffice for V(D)J recombination.
@ast
Both V(D)J recombination and r ...... ffice for V(D)J recombination.
@en
prefLabel
Both V(D)J recombination and r ...... ffice for V(D)J recombination.
@ast
Both V(D)J recombination and r ...... ffice for V(D)J recombination.
@en
P2093
P2860
P356
P1476
Both V(D)J recombination and r ...... ffice for V(D)J recombination.
@en
P2093
P2860
P304
P356
10.1093/NAR/28.14.2752
P407
P577
2000-07-01T00:00:00Z