PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria - Test2 - elhamkhani - TriplyDB

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

http://www.wikidata.org/entity/Q28384526

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The phosphorylation-dependent regulation of mitochondrial proteins in stress responses Role of Nrf2 in oxidative stress and toxicity Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1 Advances in mechanisms of anti-oxidation NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics Reactive oxygen species and mitochondria: A nexus of cellular homeostasis Fueling the flames: Mammalian programmed necrosis in inflammatory diseases Redox regulation of mitochondrial biogenesis The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans Stress-activated cap'n'collar transcription factors in aging and human disease The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.Regulation of proteasome activity in health and disease Cytoprotection "gone astray": Nrf2 and its role in cancer Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis Nrf2 protects mitochondrial decay by oxidative stress Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development Computational classification of mitochondrial shapes reflects stress and redox state.Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5.Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder.Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model Spatial and temporal dynamics of the cardiac mitochondrial proteome.Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.

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P2860

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

http://www.wikidata.org/entity/Q28384526

description

2008 nî lūn-bûn

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2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2008 թվականի մայիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

@ast

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

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PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

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type

label

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

@ast

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

@en

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

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prefLabel

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

@ast

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

@en

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

@nl

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J.YEXCR.2008.02.014

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Experimental Cell Research

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PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

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Mark Hannink

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Shih-Ching Lo

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P2860

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells

The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking

Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis

Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein.

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

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10.1016/J.YEXCR.2008.02.014

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