Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function
about
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activitiesDLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migrationDLC1 negatively regulates angiogenesis in a paracrine fashionFrom mechanical force to RhoA activationEpidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2ADLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanismTensin1 positively regulates RhoA activity through its interaction with DLC1Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cellsNuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivoSolution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation.GAP-independent functions of DLC1 in metastasis.Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process.DLC1 expression is reduced in human cutaneous melanoma and correlates with patient survival.PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
P2860
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P2860
Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Mutations in the focal adhesio ...... their expression and function
@ast
Mutations in the focal adhesio ...... their expression and function
@en
Mutations in the focal adhesio ...... their expression and function
@nl
type
label
Mutations in the focal adhesio ...... their expression and function
@ast
Mutations in the focal adhesio ...... their expression and function
@en
Mutations in the focal adhesio ...... their expression and function
@nl
prefLabel
Mutations in the focal adhesio ...... their expression and function
@ast
Mutations in the focal adhesio ...... their expression and function
@en
Mutations in the focal adhesio ...... their expression and function
@nl
P2860
P1433
P1476
Mutations in the focal adhesio ...... their expression and function
@en
P2093
Yi-Ping Shih
P2860
P304
P356
10.1158/0008-5472.CAN-08-2042
P407
P50
P577
2008-10-01T00:00:00Z