p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities
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Vascular anomalies: from genetics toward models for therapeutic trialsDeleted in liver cancer-1 (DLC1): an emerging metastasis suppressor geneRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cellsDLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activityThe RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrityDLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanismDLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domainFull activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptideRole of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine fingerDeciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphomaNuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivoNf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathwaysIn vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cellsRASAL2 activates RAC1 to promote triple-negative breast cancer progressionTranscriptional network analysis reveals that AT1 and AT2 angiotensin II receptors are both involved in the regulation of genes essential for glioma progression.Cell proliferation and oxidative stress pathways are modified in fibroblasts from Sturge-Weber syndrome patientsRegulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation.GAP-independent functions of DLC1 in metastasis.RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNAmiR-31 promotes oncogenesis in intrahepatic cholangiocarcinoma cells via the direct suppression of RASA1.Inhibition of cell migration and invasion mediated by the TAT-RasGAP317-326 peptide requires the DLC1 tumor suppressor.FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer.Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading.PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
P2860
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P2860
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@ast
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@en
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@en-gb
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@nl
type
label
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@ast
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@en
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@en-gb
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@nl
prefLabel
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@ast
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@en
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@en-gb
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@nl
P2093
P2860
P356
P1433
P1476
p120Ras-GAP binds the DLC1 Rho ...... growth-suppressing activities
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2008.498
P407
P577
2009-03-19T00:00:00Z
P5875
P6179
1041025995