A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance - Test2 - elhamkhani - TriplyDB

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

http://www.wikidata.org/entity/Q28395203

about

DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets Molecular mechanisms in multiple myeloma drug resistance The 26S proteasome is a multifaceted target for anti-cancer therapies Targeting the ubiquitin pathway for cancer treatment Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20 JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15 Deubiquitinases (DUBs) and DUB inhibitors: a patent review Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.The ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumors Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.CSNK1α1 mediates malignant plasma cell survival.Inhibitory effect of b-AP15 on the 20S proteasome Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells Therapeutic landscape of carfilzomib and other modulators of the ubiquitin-proteasome pathway.Deubiquitinases in cancer.Discovery of an Inhibitor of the Proteasome Subunit Rpn11.UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1 Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment.The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor.Understanding biology to tackle the disease: Multiple myeloma from bench to bedside, and back.SCF ubiquitin ligase-targeted therapies.DUBs, the regulation of cell identity and disease.

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A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

http://www.wikidata.org/entity/Q28395203

description

2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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name

A novel small molecule inhibit ...... vercomes bortezomib resistance

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A novel small molecule inhibit ...... vercomes bortezomib resistance

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A novel small molecule inhibit ...... vercomes bortezomib resistance

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type

label

A novel small molecule inhibit ...... vercomes bortezomib resistance

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A novel small molecule inhibit ...... vercomes bortezomib resistance

@en

A novel small molecule inhibit ...... vercomes bortezomib resistance

@nl

prefLabel

A novel small molecule inhibit ...... vercomes bortezomib resistance

@ast

A novel small molecule inhibit ...... vercomes bortezomib resistance

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A novel small molecule inhibit ...... vercomes bortezomib resistance

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A novel small molecule inhibit ...... vercomes bortezomib resistance

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Arghya Ray

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Dharminder Chauhan

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Ruben D Carrasco

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Stig Linder

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Xin Wang

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Yu-Tzu Tai

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Ze Tian

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P2860

Arsenite-induced Cdc25C Degradation is through the KEN-box and Ubiquitin-proteasome Pathway

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.

Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases

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706-716

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1020040

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5

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Pádraig D'arcy

Kenneth C Anderson

Paul G Richardson

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2013-12-06T00:00:00Z

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259249645

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