Formation of toxic oligomeric alpha-synuclein species in living cells - Test2 - elhamkhani - TriplyDB

Formation of toxic oligomeric alpha-synuclein species in living cells

Formation of toxic oligomeric alpha-synuclein species in living cells

http://www.wikidata.org/entity/Q28472448

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alpha-Synuclein and neuronal cell death Structures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein protein α-Synuclein modifies huntingtin aggregation in living cells The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.Melatonin and Other Tryptophan Metabolites Produced by Yeasts: Implications in Cardiovascular and Neurodegenerative Diseases Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Biophysical characterization of α-synuclein and its controversial structure Exploring the accessible conformations of N-terminal acetylated α-synuclein Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases Function and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescence Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders Antibodies against alpha-synuclein reduce oligomerization in living cells Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo.Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers Detecting morphologically distinct oligomeric forms of alpha-synuclein.In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis.Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.Hsp70 and its molecular role in nervous system diseases Quantitative analysis of α-synuclein solubility in living cells using split GFP complementation Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.Development and screening of contrast agents for in vivo imaging of Parkinson's disease.Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

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P2860

Formation of toxic oligomeric alpha-synuclein species in living cells

http://www.wikidata.org/entity/Q28472448

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Formation of toxic oligomeric alpha-synuclein species in living cells

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Formation of toxic oligomeric alpha-synuclein species in living cells

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Formation of toxic oligomeric alpha-synuclein species in living cells

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type

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Formation of toxic oligomeric alpha-synuclein species in living cells

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Formation of toxic oligomeric alpha-synuclein species in living cells

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Formation of toxic oligomeric alpha-synuclein species in living cells

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prefLabel

Formation of toxic oligomeric alpha-synuclein species in living cells

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Formation of toxic oligomeric alpha-synuclein species in living cells

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Formation of toxic oligomeric alpha-synuclein species in living cells

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Julie E Tetzlaff

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Mirjam Koker

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Tiago Fleming Outeiro

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P2860

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Parkinson's disease: mechanisms and models

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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