Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. - Test2 - elhamkhani - TriplyDB

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

http://www.wikidata.org/entity/Q33714875

about

PINK1 cleavage at position A103 by the mitochondrial protease PARL.Chaperones in Neurodegeneration Targeting heat shock proteins to modulate α-synuclein toxicity Molecular chaperones and co-chaperones in Parkinson disease Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90 Alpha-synuclein biology in Lewy body diseases Alpha-synuclein and tau: teammates in neurodegeneration?Inhibition of heat-shock protein 90 reduces Ebola virus replication Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex Heat shock proteins: cellular and molecular mechanisms in the central nervous system.In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin.ER stress response plays an important role in aggregation of α-synuclein Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Molecular chaperones in Parkinson's disease--present and future Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells.A novel approach to recovery of function of mutant proteins by slowing down translation.A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.Exosomal cell-to-cell transmission of alpha synuclein oligomers.α-synuclein interacts with SOD1 and promotes its oligomerization.A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo.Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction α-Synuclein oligomers and clinical implications for Parkinson disease.Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.Direct detection of alpha synuclein oligomers in vivo Identification of chaperones in a MPP+-induced and ATRA/TPA-differentiated SH-SY5Y cell PD model.Protein Quality Control by Molecular Chaperones in Neurodegeneration.

P2860

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P2860

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

http://www.wikidata.org/entity/Q33714875

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Brain-permeable small-molecule ...... ha-synuclein-induced toxicity.

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Brain-permeable small-molecule ...... ha-synuclein-induced toxicity.

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type

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Brain-permeable small-molecule ...... ha-synuclein-induced toxicity.

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Brain-permeable small-molecule ...... ha-synuclein-induced toxicity.

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Brain-permeable small-molecule ...... ha-synuclein-induced toxicity.

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Brain-permeable small-molecule ...... ha-synuclein-induced toxicity.

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Brain-permeable small-molecule ...... ha-synuclein-induced toxicity.

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Anisa Scott

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Carol D Hicks

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James M Veal

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Karin M Danzer

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Lisa R Kranich

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Melanie Silinski

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Pamela J McLean

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Paul M Steed

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Preeti Putcha

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Sarah Mabbett

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P2860

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Alpha-synuclein in Lewy bodies

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

Purine-scaffold Hsp90 inhibitors

Formation of toxic oligomeric alpha-synuclein species in living cells

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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849-857

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