Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells - Test2 - elhamkhani - TriplyDB

Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells

Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells

http://www.wikidata.org/entity/Q28474736

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PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene.Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer Epigenetic control of gene expression in the alcoholic brain Genomic instability in liver cells caused by an LPS-induced bystander-like effect Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells.UHRF1 is required for basal stem cell proliferation in response to airway injury.Proximity ligation in situ assay for monitoring the global DNA methylation in cells PKC isoforms interact with and phosphorylate DNMT1 TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.DNA methylation: superior or subordinate in the epigenetic hierarchy?DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos Regulation of mammalian DNA methyltransferases: a route to new mechanisms.The lytic phase of epstein-barr virus requires a viral genome with 5-methylcytosine residues in CpG sites.The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle.RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma.Regulation of DNA methylation in rheumatoid arthritis synoviocytes.Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence Glutamine contributes to maintenance of mouse embryonic stem cell self-renewal through PKC-dependent downregulation of HDAC1 and DNMT1/3a Epigenetic regulation of estrogen signaling in breast cancer Specific inhibition of one DNMT1-including complex influences tumor initiation and progression.Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures.Ub-family modifications at the replication fork: Regulating PCNA-interacting components.Emerging roles for chromatin as a signal integration and storage platform.Aberrant DNA methylation in human cancers.Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications DNA methylation and apoptosis resistance in cancer cells Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis Epigenetics in NG2 glia cells.Epigenetic Regulation.The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm.Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape.Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells.Enzymology of Mammalian DNA Methyltransferases.

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Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells

http://www.wikidata.org/entity/Q28474736

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Disruption of Dnmt1/PCNA/UHRF1 ...... rom human and mice glial cells

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Audrey Geairon

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Emilie Debien

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Eric Hervouet

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François M Vallette

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Stéphane A Martin

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P2860

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression

Replication-independent chromatin loading of Dnmt1 during G2 and M phases

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

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Delphine Loussouarn

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45102357

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