The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures. - Test2 - elhamkhani - TriplyDB

The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures.

The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures.

http://www.wikidata.org/entity/Q37642498

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Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells.In vitro experimental models of mesothelioma revisited Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression.Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy.Cell-specific pattern of berberine pleiotropic effects on different human cell lines.

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The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures.

http://www.wikidata.org/entity/Q37642498

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 March 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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The DNMT1/PCNA/UHRF1 disruptio ...... tic and epigenetic signatures.

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The DNMT1/PCNA/UHRF1 disruptio ...... tic and epigenetic signatures.

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type

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The DNMT1/PCNA/UHRF1 disruptio ...... tic and epigenetic signatures.

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The DNMT1/PCNA/UHRF1 disruptio ...... tic and epigenetic signatures.

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prefLabel

The DNMT1/PCNA/UHRF1 disruptio ...... tic and epigenetic signatures.

@en

The DNMT1/PCNA/UHRF1 disruptio ...... tic and epigenetic signatures.

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Scientific Reports

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The DNMT1/PCNA/UHRF1 disruptio ...... tic and epigenetic signatures.

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Emeline Brocard

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Lisenn Lalier

http://www.w3.org/2001/XMLSchema#string

Romain Pacaud

http://www.w3.org/2001/XMLSchema#string

P2860

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

High sensitivity mapping of methylated cytosines

A method for accurate detection of genomic microdeletions using real-time quantitative PCR.

Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation

Epigenetics in cancer

Direct observation of individual endogenous protein complexes in situ by proximity ligation

Proximity ligation in situ assay for monitoring the global DNA methylation in cells

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells.

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4230

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scholarly article

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10.1038/SREP04230

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4

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Pierre-Francois Cartron

François M Vallette

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2014-03-18T00:00:00Z

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260874802

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1019786457

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24637615

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3957150

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