Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice
about
Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungsNovel adjunctive therapies for the treatment of tuberculosisPersistent high mortality in advanced HIV/TB despite appropriate antiretroviral and antitubercular therapy: an emerging challengeTargeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacyPhosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathologySuccessful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse modelAdjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomasIdentification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growthNew tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeuticsMacrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis.Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.Reactivation of M. tuberculosis infection in trans-membrane tumour necrosis factor mice.Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary tuberculosisSimvastatin increases the in vivo activity of the first-line tuberculosis regimen.Advancing host-directed therapy for tuberculosis.Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infectionStrain specific transcriptional response in Mycobacterium tuberculosis infected macrophages.Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model.Gr-1dimCD11b+ immature myeloid-derived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in miceRoflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis.Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model.Adjuvant host-directed therapy with types 3 and 5 but not type 4 phosphodiesterase inhibitors shortens the duration of tuberculosis treatmentPharmacologic Inhibition of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance of Mycobacterium tuberculosis.Tumor necrosis factor neutralization combined with chemotherapy enhances Mycobacterium tuberculosis clearance and reduces lung pathology.Challenges and opportunities in developing novel drugs for TB.Immunity to TB and targets for immunotherapy.Host-directed therapeutics for tuberculosis: can we harness the host?Host-Directed Therapies for Tuberculosis.Inhibition of Phosphodiesterase-4 during Pneumococcal Pneumonia Reduces Inflammation and Lung Injury in Mice.RNAseq reveals hypervirulence-specific host responses to M. tuberculosis infectionHost-Directed Therapeutic Strategies for Tuberculosis.Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials.
P2860
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P2860
Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@ast
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@en
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@nl
type
label
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@ast
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@en
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@nl
prefLabel
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@ast
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@en
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@nl
P2093
P2860
P3181
P1433
P1476
Phosphodiesterase 4 inhibition ...... in the lungs of infected mice
@en
P2093
Claudia Manca
Dorothy Fallows
George Muller
Guibin Yang
Liana Tsenova
Mi-Sun Koo
Nackmoon Sung
Paul O'Brien
Sabine Ehrt
Selvakumar Subbian
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0017091
P407
P50
P577
2011-02-25T00:00:00Z