Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice - Test2 - elhamkhani - TriplyDB

Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice

Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice

http://www.wikidata.org/entity/Q28477281

about

Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs Novel adjunctive therapies for the treatment of tuberculosis Persistent high mortality in advanced HIV/TB despite appropriate antiretroviral and antitubercular therapy: an emerging challenge Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis.Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.Reactivation of M. tuberculosis infection in trans-membrane tumour necrosis factor mice.Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary tuberculosis Simvastatin increases the in vivo activity of the first-line tuberculosis regimen.Advancing host-directed therapy for tuberculosis.Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages.Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model.Gr-1dimCD11b+ immature myeloid-derived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice Roflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis.Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model.Adjuvant host-directed therapy with types 3 and 5 but not type 4 phosphodiesterase inhibitors shortens the duration of tuberculosis treatment Pharmacologic Inhibition of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance of Mycobacterium tuberculosis.Tumor necrosis factor neutralization combined with chemotherapy enhances Mycobacterium tuberculosis clearance and reduces lung pathology.Challenges and opportunities in developing novel drugs for TB.Immunity to TB and targets for immunotherapy.Host-directed therapeutics for tuberculosis: can we harness the host?Host-Directed Therapies for Tuberculosis.Inhibition of Phosphodiesterase-4 during Pneumococcal Pneumonia Reduces Inflammation and Lung Injury in Mice.RNAseq reveals hypervirulence-specific host responses to M. tuberculosis infection Host-Directed Therapeutic Strategies for Tuberculosis.Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials.

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Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice

http://www.wikidata.org/entity/Q28477281

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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Phosphodiesterase 4 inhibition ...... in the lungs of infected mice

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Phosphodiesterase 4 inhibition ...... in the lungs of infected mice

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Phosphodiesterase 4 inhibition ...... in the lungs of infected mice

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Claudia Manca

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Dorothy Fallows

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George Muller

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Guibin Yang

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Liana Tsenova

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Mi-Sun Koo

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Sabine Ehrt

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Selvakumar Subbian

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P2860

Mycobacterium tuberculosis in the Extracellular Compartment: an Underestimated Adversary

Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue

Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

The ubiquitin-like protein FAT10 forms covalent conjugates and induces apoptosis

Immunology of tuberculosis

Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program

Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages

Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice

Toll-like receptors control autophagy.

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21364878

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Mycobacterium tuberculosis

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3045423

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