FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS - Test2 - elhamkhani - TriplyDB

FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS

FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS

http://www.wikidata.org/entity/Q28484269

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Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations Highly efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neurons Transportin-1 and Transportin-2: protein nuclear import and beyond.Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules Variants in HNRNPH2 on the X Chromosome Are Associated with a Neurodevelopmental Disorder in Females.Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma.The role of FUS gene variants in neurodegenerative diseases.Factors influencing the nuclear targeting ability of nuclear localization signals.Nuclear trafficking in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.NLS-tagging: an alternative strategy to tag nuclear proteins.TDP-43/FUS in motor neuron disease: Complexity and challenges.Utility of whole exome sequencing in evaluation of juvenile motor neuron disease.Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis.Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U.Genetic mutations in RNA-binding proteins and their roles in ALS.Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.A novel mutation of the C-terminal amino acid of FUS (Y526C) strengthens FUS gene as the most frequent genetic factor in aggressive juvenile ALS.Fused in Sarcoma Neuropathology in Neurodegenerative Disease.The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS.The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration

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FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS

http://www.wikidata.org/entity/Q28484269

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2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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FUS-NLS/Transportin 1 complex ...... US and the implications in ALS

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FUS-NLS/Transportin 1 complex ...... US and the implications in ALS

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FUS-NLS/Transportin 1 complex ...... US and the implications in ALS

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FUS-NLS/Transportin 1 complex ...... US and the implications in ALS

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FUS-NLS/Transportin 1 complex ...... US and the implications in ALS

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FUS-NLS/Transportin 1 complex ...... US and the implications in ALS

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Chunyan Niu

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Feng Gao

http://www.w3.org/2001/XMLSchema#string

Haining Zhu

http://www.w3.org/2001/XMLSchema#string

Jiayu Zhang

http://www.w3.org/2001/XMLSchema#string

Liuqing Yang

http://www.w3.org/2001/XMLSchema#string

Minze Jia

http://www.w3.org/2001/XMLSchema#string

Weimin Gong

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P2860

Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

Rules for nuclear localization sequence recognition by karyopherin beta 2

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

Structure-based design of a pathway-specific nuclear import inhibitor

Structural basis for substrate recognition and dissociation by human transportin 1

Structural and energetic basis of ALS-causing mutations in the atypical proline–tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)

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10.1371/JOURNAL.PONE.0047056

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232233168

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23056579

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amyotrophic lateral sclerosis

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