ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
about
FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitmentAltered ribostasis: RNA-protein granules in degenerative disordersEvaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosisNuclear transport, oxidative stress, and neurodegenerationConjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSInside out: the role of nucleocytoplasmic transport in ALS and FTLDMechanisms of FUS mutations in familial amyotrophic lateral sclerosisDysregulated axonal RNA translation in amyotrophic lateral sclerosisPrion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseaseFUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysisAlterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisThe function of RNA-binding proteins at the synapse: implications for neurodegenerationRedox regulation in amyotrophic lateral sclerosisCytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosisFUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degenerationStructural and energetic basis of ALS-causing mutations in the atypical proline–tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neuronsTDP-43 aggregation in neurodegeneration: are stress granules the key?A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Emerging mechanisms of molecular pathology in ALSEngineering enhanced protein disaggregases for neurodegenerative diseaseDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseTransportin1: a marker of FTLD-FUSOxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutationsFUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALSIdentification of genetic modifiers of TDP-43 neurotoxicity in DrosophilaFUS Interacts with HSP60 to Promote Mitochondrial DamageEWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functionsAberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosisAre aberrant phase transitions a driver of cellular aging?Mutational analysis of FUS gene and its structural and functional role in amyotrophic lateral sclerosis 6.Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm
P2860
Q24305570-8F5B706B-F339-4762-814B-0F362FE3B163Q24604643-DD4627AA-9860-47D3-BFF9-062EF7C86A57Q24605104-D509251E-6BD2-4510-8758-31A2EE6D5FC8Q24624357-836AFDD3-A511-4A17-BE01-66B9831C251AQ24634807-4E96AB49-1F62-4C4C-848A-F1A3D5B00DD2Q26748482-E91CA293-25E5-46A1-8B1C-165A32640207Q26749169-55B039A9-307F-4272-BB42-EAEE49FA2BD1Q26753110-C281FBC7-F611-41B7-8343-469ED149F53BQ26753190-B0E46519-0EFC-45FD-9FEC-37009257E403Q26773038-F75F254A-EE61-4783-AA6C-CD298C50B9C4Q26777971-43D5C590-E340-4DC2-A718-72FA38B15E83Q26799233-E192A958-29F4-47D5-8C83-9E2A2893B24FQ26828357-3BA224B6-3F11-46F7-90A4-138FBC000E65Q26863439-F220E4DE-F62B-4266-8FA3-E2D866DF420EQ26991684-C8EF31B2-A618-426F-B431-844CEC6B9758Q27026894-C5039CD5-6E6A-4E9B-8A1E-8D2609184703Q27301265-8B9A14EA-CCAB-4F5A-BBEE-3541EC5DF619Q27334411-6F25287C-FCF1-4B16-8CD2-65C9C6C100C1Q27339258-1C75F74A-D995-48DC-855A-D95CDBEB5548Q27342067-1F4DDA20-BE42-4512-9824-DE5C16AEBE5CQ27670694-A094EAD9-D44E-4537-B268-BC5F8A4D28BFQ27674359-A7F30CA5-2F51-43FB-8F64-B23B85E3AD40Q27692111-4191CB57-F8A3-4CBD-B421-0350F01FA819Q28079299-75BEBBC0-E2D0-4E23-82AD-C2353267CE84Q28080628-418F8BDB-0514-4DAA-9455-DDDFC81B9C5DQ28081239-BE83EDEC-2BFF-4507-AC4B-C896CB3FC8FBQ28083809-679A2F95-4300-4B06-A1F0-2A1E31DF6FB6Q28088777-F349C5EF-57A9-4ADC-B55D-FCC751BA7982Q28245695-111C27AE-3D1E-4465-9A61-0A09F35F7C03Q28383058-097999C1-60C8-41EF-85AB-44F306AB5681Q28484269-5E687F4F-2574-4DC7-A464-98DAA96DA7ABQ28487048-B471DCA4-A69C-4250-8525-2DE48DFA8372Q28547727-BEB17C5B-6F84-487D-AF7F-EF927A8CC843Q28607398-30797966-66AC-44A4-95ED-AAD8D0156927Q28730723-C1BFE503-ACD1-4B7E-9ED4-C87AD10CBFFEQ28821465-6437AD1F-CC4F-4E6A-BA03-26F39E663032Q30361415-63CF8208-8774-4FCC-9E8B-AED95EDE8A6BQ30532680-6FCEE98C-C518-4724-8253-16D91ACBFD52Q30541711-03A7A6C7-7433-4869-A724-5EA2C086D834Q30559680-165201AF-9C46-4B1A-93D1-D0B47E664D43
P2860
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@ast
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@en
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@nl
type
label
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@ast
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@en
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@nl
prefLabel
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@ast
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@en
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
ALS-associated fused in sarcom ...... portin-mediated nuclear import
@en
P2093
Alexander Hruscha
Bettina Schmid
Dorothee Dormann
Eva Bentmann
Ian R A Mackenzie
Ingeborg Fischer
Manuel E Than
Ramona Rodde
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.143
P407
P577
2010-08-18T00:00:00Z