Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis
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Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetesModify or die?--RNA modification defects in metazoansDeficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in miceA Common Susceptibility Gene for Type 2 Diabetes Is Associated with Drug Response to a DPP-4 Inhibitor: Pharmacogenomic Cohort in Okinawa JapanIndividualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis.Whole Genome Association Studies of Residual Feed Intake and Related Traits in the Pig.The search for genetic risk factors of type 2 diabetes mellitus.Whole genome SNP genotyping and exome sequencing reveal novel genetic variants and putative causative genes in congenital hyperinsulinism.CDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children.Significance of a common variant in the CDKAL1 gene with susceptibility to type 2 diabetes mellitus in Iranian populationAssociation of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study).Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells.Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 MiceAssociation of rs7754840 G/C polymorphisms in CDKAL1 with type 2 diabetes: a meta-analysis of 70141 subjects.Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets.CDKAL1 gene rs7756992 A/G polymorphism and type 2 diabetes mellitus: a meta-analysis of 62,567 subjects.From mice to humans.An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells.CDK5 Regulatory Subunit-Associated Protein 1-like 1 Negatively Regulates Adipocyte Differentiation through Activation of Wnt Signaling PathwayCdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue.The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study.
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P2860
Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis
description
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
@fr
artículu científicu espublizáu en 2010
@ast
im Dezember 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/12/09)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/12/09)
@nl
наукова стаття, опублікована в грудні 2010
@uk
name
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@ast
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@en
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@nl
type
label
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@ast
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@en
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@nl
prefLabel
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@ast
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@en
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@nl
P2093
P2860
P921
P3181
P1433
P1476
Deletion of CDKAL1 affects mit ...... first-phase insulin exocytosis
@en
P2093
Chiyono Nishiwaki
Hayato Kawakami
Hitoshi Takenaka
Kyota Aoyagi
Masafumi Kakei
Masashi Yoshida
Mica Ohara-Imaizumi
Norihiro Kato
Rieko Takanashi-Yanobu
Shin-ichi Hisanaga
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0015553
P407
P577
2010-12-09T00:00:00Z