Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice
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tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humansLeptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individualsIslet inflammation: a unifying target for diabetes treatment?Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNAMethylated nucleosides in tRNA and tRNA methyltransferasesTreatment of type 2 diabetes, lifestyle, GLP1 agonists and DPP4 inhibitorsDeletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetesTwo Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferasesThe tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmLA cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification.Genome recoding by tRNA modificationsModify or die?--RNA modification defects in metazoansDiscovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAsThe crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamilyBridging the gap between genetic associations and molecular mechanisms for type 2 diabetes.Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a Han Chinese population.Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAsRadical SAM enzymes in methylation and methylthiolationEmerging themes in radical SAM chemistryDifferent types of secondary information in the genetic code.In vitro biosynthesis of a universal t6A tRNA modification in Archaea and EukaryaAdaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis.Recent advances in radical SAM enzymology: new structures and mechanisms.RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.Profiling of cis-diol-containing nucleosides and ribosylated metabolites by boronate-affinity organic-silica hybrid monolithic capillary liquid chromatography/mass spectrometry.A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1Prediction of uridine modifications in tRNA sequencesAssociation of variants in CDKN2A/2B and CDKAL1 genes with gestational insulin sensitivity and disposition in pregnant Han Chinese women.Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes.Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 MiceIdentification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase.Association of rs7754840 G/C polymorphisms in CDKAL1 with type 2 diabetes: a meta-analysis of 70141 subjects.Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearanceOxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells.Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets.Genetic variants associated with lean and obese type 2 diabetes in a Han Chinese population: A case-control study.Lack of tRNA modification isopentenyl-A37 alters mRNA decoding and causes metabolic deficiencies in fission yeast.Genetic modifiers of cystic fibrosis-related diabetesThe pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunctionCDKAL1 gene rs7756992 A/G polymorphism and type 2 diabetes mellitus: a meta-analysis of 62,567 subjects.
P2860
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P2860
Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice
description
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im September 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/09/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/09/01)
@nl
наукова стаття, опублікована у вересні 2011
@uk
مقالة علمية (نشرت في سبتمبر 2011)
@ar
name
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@ast
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@en
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@nl
type
label
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@ast
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@en
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@nl
prefLabel
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@ast
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@en
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Deficit of tRNA(Lys) modificat ...... ent of type 2 diabetes in mice
@en
P2093
Fan-Yan Wei
Hideki Matsui
Hiroyuki Michiue
Kazuhito Tomizawa
Kazuya Yamagata
Mohamed Atta
Satoshi Kimura
Sayaka Watanabe
Takeo Suzuki
Taku Kaitsuka
P2860
P304
P3181
P356
10.1172/JCI58056
P407
P577
2011-09-01T00:00:00Z