Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death
about
Visual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoterG-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptorSerine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPLRetinal insulin receptor signaling in hyperosmotic stressThe role of Akt/protein kinase B subtypes in retinal ischemic preconditioningAll Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.Phospho-Site-Specific Antibody Microarray to Study the State of Protein Phosphorylation in the Retina.Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene.Rhodopsin-regulated insulin receptor signaling pathway in rod photoreceptor neurons.Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.Phosphoinositide 3-kinase signaling in retinal rod photoreceptors.Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival.Conservation and divergence of Grb7 family of Ras-binding domainsCone Viability Is Affected by Disruption of Melatonin Receptors SignalingClinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina?Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina.Insulin receptor signaling in cones.Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositidesInsulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors.Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or functionLight activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotectionEndogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degenerationInsulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors.Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation.Modulation of mouse rod photoreceptor responses by Grb14 protein.The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina.Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptorsPhosphoinositide 3-kinase signaling in the vertebrate retina.Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish.Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal.Conditional gene targeting: dissecting the cellular mechanisms of retinal degenerations.Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development.Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment.Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice.Protective effects of placental growth factor on retinal neuronal cell damage.The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration.Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.
P2860
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P2860
Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death
description
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Januar 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/01/03)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/01/03)
@nl
наукова стаття, опублікована в січні 2007
@uk
مقالة علمية (نشرت في 3-1-2007)
@ar
name
Nonredundant role of Akt2 for ...... from light-induced cell death
@ast
Nonredundant role of Akt2 for ...... from light-induced cell death
@en
Nonredundant role of Akt2 for ...... from light-induced cell death
@nl
type
label
Nonredundant role of Akt2 for ...... from light-induced cell death
@ast
Nonredundant role of Akt2 for ...... from light-induced cell death
@en
Nonredundant role of Akt2 for ...... from light-induced cell death
@nl
prefLabel
Nonredundant role of Akt2 for ...... from light-induced cell death
@ast
Nonredundant role of Akt2 for ...... from light-induced cell death
@en
Nonredundant role of Akt2 for ...... from light-induced cell death
@nl
P2093
P921
P1476
Nonredundant role of Akt2 for ...... from light-induced cell death
@en
P2093
Guiyuan Li
Raju V S Rajala
Robert E Anderson
Ruben Adler
Xiaochun Liu
P304
P356
10.1523/JNEUROSCI.0445-06.2007
P407
P577
2007-01-03T00:00:00Z