Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
about
Single-gene mutations and healthy ageing in mammalsBrain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in HumansComplex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunctionAlzheimer's Disease: Mechanism and Approach to Cell TherapyMetabolic Alterations Associated to Brain Dysfunction in DiabetesAlzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactionsAlzheimer's disease and insulin resistance: translating basic science into clinical applicationsRoles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factorsFoxO6 regulates memory consolidation and synaptic functionThe ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated miceClusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathwayThe influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathologyUncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.The new biology of ageing.Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neuronsReducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnoverBrain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.Mammalian models of extended healthy lifespan.Promoting health and longevity through diet: from model organisms to humans.Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?Does Huntingtin play a role in selective macroautophagy?A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models.Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changesIRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington diseaseEndoplasmic reticulum stress impairs insulin receptor signaling in the brains of obese ratsAn anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.Mini-review: Retarding aging in murine genetic models of neurodegenerationMitochondrial deficiency: a double-edged sword for aging and neurodegeneration.Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's diseaseUnexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging.Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging.Advanced glycation end products, dementia, and diabetesIntegrating metabolism and longevity through insulin and IGF1 signaling.
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P2860
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
description
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im August 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/08/14)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/08/14)
@nl
наукова стаття, опублікована в серпні 2009
@uk
مقالة علمية (نشرت في 14-8-2009)
@ar
name
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@ast
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@en
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@nl
type
label
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@ast
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@en
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@nl
prefLabel
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@ast
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@en
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@nl
P2093
P2860
P50
P1476
Deletion of Irs2 reduces amylo ...... eficits in APP transgenic mice
@en
P2093
Agharul I Choudhury
Claudie Hooper
Elaine E Irvine
Georgie Scales
Hind Al-Qassab
John Stephenson
K Peter Giese
Laura Drinkwater
Mirsada Causevic
Zehra Yilmaz
P2860
P304
P356
10.1016/J.BBRC.2009.06.032
P407
P577
2009-06-10T00:00:00Z