Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
about
Insulin in central nervous system: more than just a peripheral hormoneDysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesLife with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficienciesGlycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsAlzheimer's Disease: Mechanism and Approach to Cell TherapyMolecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisalMetabolic Alterations Associated to Brain Dysfunction in DiabetesIntranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the artInsulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's diseaseElevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brainInsulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndromeTherapeutic targets of brain insulin resistance in sporadic Alzheimer's diseaseRoles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factorsAberrant insulin signaling in Alzheimer's disease: current knowledgeThe physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernationInsulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liverGut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutideBrain insulin resistance and deficiency as therapeutic targets in Alzheimer's diseaseDeletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic miceRole for Akt3/protein kinase Bgamma in attainment of normal brain sizeInsulin receptor substrate 2 is required for testicular developmentThe ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated miceThe influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathologyNeurodevelopmental effects of insulin-like growth factor signaling.Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of functionPI3K integrates the action of insulin and leptin on hypothalamic neurons.Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging.Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNIInsulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy.Insulin, cognition, and dementiaDeletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?IRS-2 rs1805097 polymorphism is associated with the decreased risk of colorectal cancerInsulin action in brain regulates systemic metabolism and brain function.Evolution of the vertebrate insulin receptor substrate (Irs) gene familyCardiovascular risk factors and frontotemporal dementia: a case-control studyType 2 diabetes as a risk factor for cognitive impairment: current insights.Effect of aging on cellular mechanotransductionAlzheimer's disease is type 3 diabetes-evidence reviewed.Therapeutic perspectives of drugs targeting Toll-like receptors based on immune physiopathology theory of Alzheimer's disease.Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis.
P2860
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P2860
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@ast
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@en
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@nl
type
label
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@ast
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@en
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@nl
prefLabel
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@ast
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@en
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@nl
P2093
P921
P3181
P1476
Insulin receptor substrate-2 d ...... d promotes tau phosphorylation
@en
P2093
Carlos Rio
Carrie L Flint
Deborah J Burks
Derek P Brazil
Gabriel Corfas
Jake A Kushner
Janet Farhang-Fallah
Markus Schubert
Morris F White
P304
P3181
P356
10.1523/JNEUROSCI.23-18-07084.2003
P407
P577
2003-08-06T00:00:00Z