Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
about
A meckelin-filamin A interaction mediates ciliogenesisTMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zoneBBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypesThe Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactionsDisruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndromeMutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromesCongenital hypoplasia of the cerebellum: developmental causes and behavioral consequencesThe role of primary cilia in neuronal functionCilia in autophagy and cancerWnt/β-catenin signaling in kidney injury and repair: a double-edged swordCilia in vertebrate development and diseasePrimary cilia in the developing and mature brainScrutinizing ciliopathies by unraveling ciliary interaction networksCEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathiesInvestigating embryonic expression patterns and evolution of AHI1 and CEP290 genes, implicated in Joubert syndromeMouse models of ciliopathies: the state of the art.A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.Trafficking in and to the primary cilium.The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signalingAHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisisNeuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.Neural mechanisms underlying stress resilience in Ahi1 knockout mice: relevance to neuropsychiatric disordersThe primary cilium: a signalling centre during vertebrate developmentPreferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders.The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity.Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycleLights on for aminopeptidases in cystic kidney disease.Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisisPrimary cilia are required in a unique subpopulation of neural progenitorsCilia in the CNS: the quiet organelle claims center stageCiliopathies: the trafficking connection.Nuclear expression of β-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells.Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signalingCby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function.Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner.Subcellular spatial regulation of canonical Wnt signalling at the primary ciliumDefective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome.Cilium, centrosome and cell cycle regulation in polycystic kidney disease.β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.
P2860
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P2860
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
description
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im September 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/09/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/09/01)
@nl
наукова стаття, опублікована у вересні 2009
@uk
مقالة علمية (نشرت في سبتمبر 2009)
@ar
name
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@ast
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@en
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@nl
type
label
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@ast
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@en
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@nl
prefLabel
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@ast
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@en
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@nl
P2093
P2860
P3181
P356
P1433
P1476
Impaired Wnt-beta-catenin sign ...... ds to cystic kidney ciliopathy
@en
P2093
Carrie M. Louie
Jennifer L. Silhavy
Karl Willert
Louis Sintasath
Madeline A. Lancaster
Marvalyn Decambre
Sanjay K. Nigam
P2860
P2888
P304
P3181
P356
10.1038/NM.2010
P407
P577
2009-09-01T00:00:00Z