Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors
about
An autoinhibitory effect of the homothorax domain of Meis2Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotypeCytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translationCooperative transcriptional activation by Klf4, Meis2, and Pbx1Pbx homeodomain proteins pattern both the zebrafish retina and tectum.Cytosolic sequestration of Prep1 influences early stages of T cell development.Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesisInduction of HoxB transcription by retinoic acid requires actin polymerization.Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesisPrep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway.Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer.MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase.The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability.Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1.Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.The role of Pbx1 in T cells.Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels.Prep1 prevents premature adipogenesis of mesenchymal progenitors.Germ cell-intrinsic requirement for the homeodomain transcription factor PKnox1/Prep1 in adult spermatogenesis.PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.
P2860
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P2860
Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@ast
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@en
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@nl
type
label
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@ast
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@en
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@nl
prefLabel
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@ast
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@en
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@nl
P2093
P2860
P50
P1476
Involvement of Prep1 in the al ...... al of hematopoietic precursors
@en
P2093
Dmitri Penkov
Elisabetta Ferretti
Francesco Blasi
Patrizia Di Rosa
Veronica Basso
P2860
P304
10768-10781
P356
10.1128/MCB.25.24.10768-10781.2005
P407
P577
2005-12-01T00:00:00Z