The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
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Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.A1/Bfl-1 in leukocyte development and cell deathCXCR4 acts as a costimulator during thymic beta-selection.In vitro gene regulatory networks predict in vivo function of liverRoles of the NF-kappaB pathway in lymphocyte development and function.Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.Controlled major histocompatibility complex-T cell receptor signaling allows efficient generation of functional, antigen-specific CD8+ T cells from embryonic stem cells and thymic progenitors.The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.Life and death in the thymus--cell death signaling during T cell development.Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development.Identification of C/EBPβ target genes in ALK+ anaplastic large cell lymphoma (ALCL) by gene expression profiling and chromatin immunoprecipitation.Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cellsMonocyte-derived DC maturation strategies and related pathways: a transcriptional viewRegulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity.The essential role of evasion from cell death in cancer.Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice.The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory propertiesDefective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in miceAsymmetric cell division during T cell development controls downstream fate.Polar opposites: Erk direction of CD4 T cell subsets.Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in miceThe role of apoptosis in the development and function of T lymphocytes.Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.NF-kappaB guides the survival and differentiation of developing lymphocytes.Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development.Apoptosis in the development of the immune system.Expression of T-cell receptor genes during early T-cell development.Critical roles of the PI3K/Akt signaling pathway in T cell developmentRegulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and BidDifferential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes.Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.NFAT5 induction by the pre-T-cell receptor serves as a selective survival signal in T-lymphocyte developmentApoptosis and autophagy in the regulation of T lymphocyte functionBCL2A1: the underdog in the BCL2 family.NF-κB subunit specificity in hemopoiesis.Getting away with murder: how does the BCL-2 family of proteins kill with immunity?Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.Transcription factors and target genes of pre-TCR signaling.
P2860
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P248
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P2860
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
description
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Februar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/02/21)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/02/21)
@nl
наукова стаття, опублікована в лютому 2005
@uk
مقالة علمية (نشرت في 21-2-2005)
@ar
name
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@ast
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@en
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@nl
type
label
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@ast
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@en
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@nl
prefLabel
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@ast
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@en
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@nl
P2093
P2860
P50
P921
P356
P1476
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
@en
P2093
A Thomas Look
Adolfo A Ferrando
Christine Borowski
Fanyong Meng
Harald von Boehmer
Iannis Aifantis
Isabella Screpanti
Malay Mandal
Philipp Oberdoerffer
Stanley J Korsmeyer
P2860
P304
P356
10.1084/JEM.20041924
P407
P577
2005-02-01T00:00:00Z