BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
about
Hypoxia and defective apoptosis drive genomic instability and tumorigenesisBcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimersInvolvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infectionProteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cellsEndoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cellsHuman nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domainProapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cellsRole of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cellsThe vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein BaxPUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cellsClusterin inhibits apoptosis by interacting with activated BaxA short Nur77-derived peptide converts Bcl-2 from a protector to a killerBcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpointsOligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channelEndoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localizationDevelopment, migration, and survival of mast cellsPUMA mediates the apoptotic response to p53 in colorectal cancer cellsJNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosisFAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expressionTaspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosisThe Bcl-2 apoptotic switch in cancer development and therapyProtein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosisBH3 mimetics to improve cancer therapy; mechanisms and examplesWISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinaseProapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activityInhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondriaInduction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathwayThe structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activityA surface groove essential for viral Bcl-2 function during chronic infection in vivo.BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisionsGuards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetesXenobiotic perturbation of ER stress and the unfolded protein responseInvolvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular CarcinomaBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreApoptotic agents
P2860
Q22242660-B07503A1-FAA2-47F4-A635-A9977CDB850CQ24292693-F111BD8C-E16F-442C-A558-AF6401E7B7C4Q24294698-9E4A28B7-BED9-4005-95BB-32D5AC1CEA4BQ24294703-A81FC264-A30C-4B2D-ACC3-74FF9478C995Q24298561-59286BFD-0B23-4F8B-A616-BA235E61DFD6Q24300781-735D6E03-AE70-433E-AE69-832371165E7DQ24300849-AF686A9B-575C-4B32-93ED-FA1D8402F075Q24302151-BB7CC83D-12C1-4DFB-94B9-C34462DE41E9Q24302494-217BBAB0-B830-4045-8C27-52011867CE1DQ24303545-BA72A8B1-1026-4B44-87DA-E6258875161EQ24306494-5E6A505B-77FD-4EFE-ABE5-E8C118E8D56FQ24307770-E1896037-8535-467E-BEC2-424B65359A9FQ24310440-FB0259B6-9B9F-4DE2-9F2D-B4A3B89A55E2Q24316443-9D61981E-3413-4137-98DD-38C34212BEEDQ24316499-D82E6867-BCA5-4CE8-BD82-18767656AD98Q24319007-7294D747-B715-4438-9480-7A4BC1EC5C12Q24322034-A8D3634A-914E-435C-8DB5-48D926940DB7Q24523479-6993C650-8977-4E19-BE0A-E30504143D35Q24529124-64544006-4026-469D-84E6-A2A0DED137D0Q24540662-21879F20-4AED-45A0-88B5-E552DD3DC581Q24549674-9579AFBD-EEDF-4087-8751-3F7FD8A5DD04Q24550772-7CC2B204-590A-4E3E-837C-D4D0823EE33EQ24554008-E0BC2F83-A9DD-4E34-946B-4BBFCC3CEAC4Q24559757-A6BA1635-B4C8-483C-8AA4-5BD3655DE82EQ24603213-4CFC7666-836D-4B57-88F7-0E68388CAF94Q24620437-FBDC4B98-F40B-485F-BD7E-8CB691E2124BQ24646492-ED58A051-1F3E-4A01-8035-90678E062756Q24655483-FD8F582B-B640-48A2-A4A0-7F3329A4A109Q24672918-C14A6E99-72C4-4A13-BA90-DBF309A2019BQ24675444-4705E22F-CF39-4FAB-AE84-4596F075B73DQ24680819-B605B2C7-B64A-4F0A-9B0A-674886A83808Q24681629-826E55F5-A9A0-455B-A359-2901E39A169BQ24683846-240CCC1F-395C-4A9A-B975-51B3F5D2D422Q24817200-23AA63A2-D7A7-48E8-A535-15DFE6E70C17Q26828031-E80109DF-B3FE-4E38-8FE2-4FED047883EFQ26992217-6293BFB7-A74A-4B22-B5F8-05103CE1B750Q26998690-DA491BE8-A440-4555-BFB5-835654DD669EQ27001182-E82647A6-3F36-4759-8F53-21E5939815ACQ27002044-1AA93D6F-58F7-4D1C-839E-E754988FF52AQ27016160-B3B0011A-3273-4920-BA37-E4EB8FB5B789
P2860
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@ast
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@en
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@nl
type
label
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@ast
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@en
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@nl
prefLabel
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@ast
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@en
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@nl
P2093
P3181
P1433
P1476
BCL-2, BCL-X(L) sequester BH3 ...... diated mitochondrial apoptosis
@en
P2093
R A Flavell
S J Korsmeyer
T Lindsten
P304
P3181
P356
10.1016/S1097-2765(01)00320-3
P407
P577
2001-09-01T00:00:00Z