Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane
about
Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes.53BP2S, interacting with insulin receptor substrates, modulates insulin signalingGDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocationRab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyteClipR-59 interacts with Akt and regulates Akt cellular compartmentalizationRab10 associates with primary cilia and the exocyst complex in renal epithelial cells.Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolismPhosphoinositides: Key modulators of energy metabolismRAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes.RAB-10-Dependent Membrane Transport Is Required for Dendrite ArborizationCrystal Structures of Human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating Protein (RabGAP) Domains Reveal Critical Elements for GLUT4 TranslocationEfficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.Glucose Transporters in Cardiac Metabolism and HypertrophyInsulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilinInsulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4CInsulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocationArp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cellsMyosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon developmentMyosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cellsRab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cellsAS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membraneA Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin actionTBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytesDisruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesiclesGLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistanceInhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation.Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic miceTropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid dropletsRegulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts.Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association.The GLUT4 codeHigh basal cell surface levels of fish GLUT4 are related to reduced sensitivity of insulin-induced translocation toward GGA and AS160 inhibition in adipocytes.Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis.Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells.
P2860
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P2860
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane
description
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im April 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/04/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/04/01)
@nl
наукова стаття, опублікована у квітні 2007
@uk
مقالة علمية (نشرت في أبريل 2007)
@ar
name
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@ast
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@en
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@nl
type
label
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@ast
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@en
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@nl
prefLabel
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@ast
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@en
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@nl
P2093
P3181
P1433
P1476
Rab10, a target of the AS160 R ...... the adipocyte plasma membrane
@en
P2093
Gustav E Lienhard
Hiroyuki Sano
Jose A Chavez
Lorena Eguez
Timothy E McGraw
Tuan D Chuang
P304
P3181
P356
10.1016/J.CMET.2007.03.001
P577
2007-04-01T00:00:00Z