Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
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Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2Therapeutic Implications of Targeting AKT Signaling in MelanomaAkt isoforms in vascular diseaseInsulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndromePhosphoinositides: Key modulators of energy metabolismPosttranslational regulation of Akt in human cancerPIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cellsBiological Chemistry and Functionality of Protein Sulfenic Acids and Related Thiol ModificationsInsulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesiclesThe actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migrationAkt isoforms differentially regulate neutrophil functionsCluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membraneInsulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of AktHigh fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism.Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult ratsPower training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle.Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts.Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosisMechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted ratsHyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factorIsoform-specific regulation of Akt by PDGF-induced reactive oxygen species.Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancerRedox regulation of protein kinases.Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.An activating mutation of AKT2 and human hypoglycemia.Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle.Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinaseNovel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretionDiverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas.Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular storesAKT/GSK3 signaling pathway and schizophreniaAmplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.The role of insulin-regulated aminopeptidase in MHC class I antigen presentation.Insulin resistance in the nervous systemDevelopment of a new model system to dissect isoform specific Akt signalling in adipocytes.The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors.AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2.Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells.
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P2860
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
@nl
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
@ast
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
@en
type
label
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
@nl
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
@ast
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
@en
prefLabel
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
@nl
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
@ast
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
@en
P2860
P3181
P356
P1476
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
@en
P2093
Eva Gonzalez
Timothy E McGraw
P2860
P304
P3181
P356
10.1073/PNAS.0901933106
P407
P577
2009-04-16T00:00:00Z