DNA repair is limiting for haematopoietic stem cells during ageing
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Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repairThe DNA-damage response in human biology and diseaseMolecular pathogenesis and clinical management of Fanconi anemiaThe maize root stem cell niche: a partnership between two sister cell populationsAcute systemic DNA damage in youth does not impair immune defense with agingAging of hematopoietic stem cells: DNA damage and mutations?Therapeutic Targeting of TelomeraseDNA Damage Response in Hematopoietic Stem Cell AgeingGenetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell FunctionChanges in Regenerative Capacity through LifespanFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workEpigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesisImmunosenescence and organ transplantationSirtuins in hematological aging and malignancyLifespan extension by preserving proliferative homeostasis in DrosophilaStructural Insights into the Role of Domain Flexibility in Human DNA Ligase IVAdult stem cell and mesenchymal progenitor theories of aging.Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcsBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?DNA ligase IV syndrome; a reviewTif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cellsMutations in the NHEJ component XRCC4 cause primordial dwarfismLoss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscleERCC1-XPF endonuclease facilitates DNA double-strand break repairAging and immune function: molecular mechanisms to interventionsIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesFrequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during AgingThe GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse HematopoiesisHematopoiesis: an evolving paradigm for stem cell biologyWidespread genomic instability mediated by a pathway involving glycoprotein Ib alpha and Aurora B kinase.Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.Extreme growth failure is a common presentation of ligase IV deficiency.DNA damage mediated s and g(2) checkpoints in human embryonal carcinoma cellsExonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells.Ionizing radiation and aging: rejuvenating an old idea.Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells.Dissecting mammalian immunity through mutation.Cdc42 and aging of hematopoietic stem cells.
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P2860
DNA repair is limiting for haematopoietic stem cells during ageing
description
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2007
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scientific journal article
@en
vedecký článok (publikovaný 2007/06/07)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/06/07)
@nl
наукова стаття, опублікована в червні 2007
@uk
مقالة علمية (نشرت في 7-6-2007)
@ar
name
DNA repair is limiting for haematopoietic stem cells during ageing
@ast
DNA repair is limiting for haematopoietic stem cells during ageing
@en
DNA repair is limiting for haematopoietic stem cells during ageing
@nl
type
label
DNA repair is limiting for haematopoietic stem cells during ageing
@ast
DNA repair is limiting for haematopoietic stem cells during ageing
@en
DNA repair is limiting for haematopoietic stem cells during ageing
@nl
prefLabel
DNA repair is limiting for haematopoietic stem cells during ageing
@ast
DNA repair is limiting for haematopoietic stem cells during ageing
@en
DNA repair is limiting for haematopoietic stem cells during ageing
@nl
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P3181
P356
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P1476
DNA repair is limiting for haematopoietic stem cells during ageing
@en
P2093
Alessandro Vindigni
Anastasia Nijnik
Caterina Marchetti
Christopher C. Goodnow
Erik Cabuy
John I. Bell
Lisa Woodbine
Neil P. Rodrigues
Penelope A. Jeggo
P2888
P304
P3181
P356
10.1038/NATURE05875
P407
P577
2007-06-07T00:00:00Z
P5875
P6179
1000568054