Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
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Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutationsKnockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemiaElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsHuman mitochondrial DNA replicationInflammation, mitochondria, and the inhibition of adult neurogenesisMitochondrial genome changes and neurodegenerative diseasesSuccinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutantPolg2 is essential for mammalian embryogenesis and is required for mtDNA maintenanceMitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesisMitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila.DNA polymerase delta is required for early mammalian embryogenesis.Mitochondrial DNA replication: a PrimPol perspective.Control of mitochondrial integrity in ageing and diseaseHigh-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development.DNA polymerases in the mitochondria: A critical review of the evidence.Mitochondrial DNA repair and association with aging--an updateThe role of mitochondrial DNA copy number in mammalian fertility.GABP transcription factor (nuclear respiratory factor 2) is required for mitochondrial biogenesis.Defects of mitochondrial DNA replication.Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory networkMitochondrial DNA mutations in disease and agingThe contribution of mitochondrial function to reproductive aging.Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repairEvolution of the metazoan mitochondrial replicase.Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function.Mitochondrial subversion in cancer.Nucleus-encoded regulators of mitochondrial function: integration of respiratory chain expression, nutrient sensing and metabolic stress.POLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity.The role of mitochondria in the pathogenesis of type 2 diabetesZebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growthMitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma AComplementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency.Mitochondrial biogenesis: a therapeutic target for neurodevelopmental disorders and neurodegenerative diseasesTWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replicationClinical and molecular features of POLG-related mitochondrial disease.Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.DNA polymerases and cancer.Mouse models of mitochondrial DNA defects and their relevance for human disease.
P2860
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P2860
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
description
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Juli 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/07/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/07/01)
@nl
наукова стаття, опублікована в липні 2005
@uk
مقالة علمية (نشرت في يوليو 2005)
@ar
name
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@ast
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@en
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@nl
type
label
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@ast
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@en
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@nl
prefLabel
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@ast
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@en
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@nl
P2860
P921
P3181
P356
P1476
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
@en
P2093
Aleksandra Trifunovic
Nicole Hance
P2860
P304
P3181
P356
10.1093/HMG/DDI184
P577
2005-05-11T00:00:00Z