Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
about
Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identityCytogenetic and molecular abnormalities in chronic myelomonocytic leukemiaEpigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical ImplicationsFunctions of TET Proteins in Hematopoietic TransformationEpigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyondMechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationCytosine modifications in neurodevelopment and diseasesConnections between TET proteins and aberrant DNA modification in cancerMechanism and function of oxidative reversal of DNA and RNA methylationThe TET2 interactors and their links to hematological malignanciesEpigenetic regulation of hematopoietic stem cell agingDose-dependent role of the cohesin complex in normal and malignant hematopoiesis.Role of TET enzymes in DNA methylation, development, and cancerEpigenetic mechanisms in heart development and diseaseDNA methylation and hydroxymethylation in stem cellsOral Azacitidine (CC-486) for the Treatment of Myelodysplastic Syndromes and Acute Myeloid LeukemiaEpigenetic Control of Smooth Muscle Cell Identity and Lineage MemoryWT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferationAccumulation of DNA damage in the aged hematopoietic stem cell compartmentGlobal epigenomic reconfiguration during mammalian brain developmentDeletion of Asxl1 results in myelodysplasia and severe developmental defects in vivoDissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine.Using Murine Models to Investigate Tumor-Lymphoid Interactions: Spotlight on Chronic Lymphocytic Leukemia and Angioimmunoblastic T-Cell Lymphoma.Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.TET enzymes, TDG and the dynamics of DNA demethylation.Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.The curious origins of angioimmunoblastic T-cell lymphomaSomatic mutations in leukocytes infiltrating primary breast cancers.Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.Epigenetic regulation of pluripotency and differentiationClonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in miceMutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neuronsA zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.DNA methylation: TET proteins-guardians of CpG islands?Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.Hydroxymethylation of DNA: an epigenetic marker.Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease
P2860
Q24633944-5FCCAA25-E891-4C56-B97A-12239F7F4961Q26768600-E9E981EE-FF22-4E3B-9EC1-159A240A7B05Q26774949-DA4EB78D-F138-461E-9039-7245BFC0ADC0Q26778323-178E9F90-D452-43E6-AF20-3E2B7485820AQ26801443-D06FA1BF-89F2-4BBA-BC81-4AB69D6298FCQ26823896-405EFD82-D1DC-41EE-9DAA-82A11ED6C04BQ26852087-51158721-B9A0-4A79-AFEF-838EB4188D20Q26865671-B9E0912B-D0AD-4EBC-82C4-A0F6885096E9Q27002361-9674DAB5-8067-4795-9E8C-DDDDCBB565EDQ27002485-26D8C97D-259F-450C-807F-E5D2FC406920Q27026054-B8957EB7-2B7F-4448-8A94-911802E990F1Q27308738-FD9190F2-87D2-4B2D-9059-BD54511B9613Q28068541-1BDEC6D2-503E-4E02-B214-7481DD928BE5Q28081134-4D22E316-E7FC-4A58-9EDB-96B2813B6B42Q28081499-BC85147E-4B0E-4234-ACB6-CFCC66E02962Q28084813-F06E4109-D01D-4209-BC47-59437D45D1A5Q28085153-2325BBCD-BC2A-4EEC-A246-EF2F0AA65296Q28255707-E8583351-3AED-409F-AFDD-10815123AC9DQ29248538-0A69E524-516F-4AC8-A09C-4440EEACF62FQ29617800-B6134D48-4648-4A73-8C98-2F9B1BB25904Q30413034-D46B4E3A-735F-4A58-B672-7982773FB8F4Q30418942-C9D6522E-2BEB-43DE-A3A8-D66CF7163781Q30448762-E3963D4A-12DB-4A40-9702-F083BF6BB425Q33621881-2A865C0E-7712-4DE0-A318-98A29F898FBDQ33697252-CDEBBC3F-F383-4D31-8FED-D54EEDB0B9BAQ33715010-757954F2-36D2-4E35-9BCE-14CDE8D16419Q33804172-A26F6A3F-9F6C-4EA3-89C3-64660036569BQ33861441-630AD929-8E06-412F-ABB8-E58C6E7EC584Q33877993-B8AE28E2-5AAF-4E7B-B660-29B742CBDC79Q33914716-D36D58A7-86A6-4635-87EC-3D1C738D9215Q34301317-DAF61F2B-C68E-478C-BB02-BAE519EC797BQ34498966-4C89646D-4A94-470D-BE49-20478F7F12DAQ34549707-EEA0F147-1EC8-4535-BDC3-C21B3A51C23AQ34651312-A71602C7-0772-43AD-B796-953F81F8EFB5Q34834731-40C16622-6DD1-445A-A63B-8524355B1301Q35069556-5DE33BD6-7AFF-444D-921A-B059D3356515Q35634706-FB3CF542-8822-4041-888C-6BEFA9178C86Q35640316-847B384F-0E7B-4F64-BC43-4E37774C05E8Q35727573-3541CB9C-4755-4E0F-B3B5-CD5E1583F1A2Q35747943-51C1EE1B-80D2-4115-AD30-5B7B2E86366F
P2860
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
description
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2011
@ast
im August 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/08/30)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/08/30)
@nl
наукова стаття, опублікована в серпні 2011
@uk
name
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@ast
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@en
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@nl
type
label
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@ast
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@en
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@nl
prefLabel
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@ast
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@en
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@nl
P2093
P2860
P50
P3181
P356
P1476
Ten-Eleven-Translocation 2 (TE ...... matopoietic stem cells in mice
@en
P2093
Anjana Rao
Edward D Lamperti
Elizabeth C Thompson
Hozefa S Bandukwala
Jungeun An
Myunggon Ko
Ryan Hastie
P2860
P304
14566-14571
P3181
P356
10.1073/PNAS.1112317108
P407
P577
2011-08-22T00:00:00Z