Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
about
HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathwayEssential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signalingTGF-β signaling via TAK1 pathway: role in kidney fibrosisTransforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermisTAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signalingTAK1 is an essential regulator of BMP signalling in cartilageHydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor geneUbiquitin signalling in the NF-kappaB pathwayA comparative analysis of extra-embryonic endoderm cell lines.MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signallingTAK1 control of cell death.Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1.Activated macrophage survival is coordinated by TAK1 binding proteinsLung organogenesisMechanism of p38 MAP kinase activation in vivo.Ena/VASP is required for endothelial barrier function in vivo.TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.Ubiquitin, TAK1 and IKK: is there a connection?TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease.TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signalingAltered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression.Generation of a conditional mutant allele for Tab1 in mouseInteraction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.Signaling pathways in early cardiac development.Current views of toll-like receptor signaling pathways.Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamilyTAK1 regulates hepatic cell survival and carcinogenesis.Transforming growth factor β activated kinase 1: a potential therapeutic target for rheumatic diseases.Post-Translational Modifications of the TAK1-TAB Complex.Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry.Expression analysis of the TAB2 protein in adult mouse tissues.O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.TAK1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle.Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.TAB1-induced auto-activation of p38α mitogen-activated protein kinase is crucially dependent on Threonine 185.The TAB1-p38α complex aggravates myocardial injury and can be targeted by small moleculesEndangered Père David's deer genome provides insights into population recovering
P2860
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P2860
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Dezember 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/12/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/01)
@nl
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في ديسمبر 2002)
@ar
name
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@ast
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@en
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@nl
type
label
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@ast
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@en
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@nl
prefLabel
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@ast
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@en
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@nl
P2093
P921
P1476
Targeted disruption of the Tab ...... ascular and lung morphogenesis
@en
P2093
Gen Yamada
Hiroshi Shibuya
Kenji Miyado
Kunihiro Matsumoto
Naoki Takeda
Teruhito Yasui
Tomohisa Sekimoto
Yoshihiro Komatsu
P304
P356
10.1016/S0925-4773(02)00391-X
P577
2002-12-01T00:00:00Z