Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen
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STE group serine/threonine-protein kinase, putativephosphatidylinositol 3-kinase, putativeCAMK/CAMKL family protein kinase, putativeMitogen-activated kinase kinase kinase, putativeCMGC/CLK family protein kinase, putativeCAMK family pseudokinase, putativeCMGC/RCK protein kinase, putativeCMGC/CLK family protein kinase, putativeAGC essential kinase 1AGC/RSK family serine/threonine kinase, putativeserine/threonine-protein kinase Nek, putativeSerine/threonine-protein kinase NEK7, putativeprotein kinase, putativeserine/threonine-protein kinase, putative5'-AMP-activated protein kinase catalytic subunit alpha, putativeserine/threonine protein kinase RIO1, putativeSTE group serine/threonine-protein kinase, putativeTOR-like 1CK1/TTBK protein kinase, putativekinatase, putativecalcium/calmodulin-dependent protein kinase, putativeAGC family serine/threonine kinase, putativeRepressor of differentiation kinase 2CMGC/DYRK protein kinase, putativeSerine/threonine-protein kinase NEK6, putativeprotein kinase , putativePseudokinase, putativecalcium/calmodulin-dependent protein kinase, putativemitogen activated protein kinase 4, putativeSTE/STE11 serine/threonine-protein kinase, putativeSTE group serine/threonine-protein kinase, putativerac serine-threonine kinase, putativeProtein kinase B, putativeSerine/threonine-protein kinase RIO2, putativecdc2-related protein kinase 11, putativeSerine/threonine-protein kinase NEK10, putativepolo-like protein kinase, putativeCMGC/SRPK protein kinase, putativecdc2-related protein kinase 7, putativeglycogen synthase kinase-3 alpha, putative
P1343
Kinases as druggable targets in trypanosomatid protozoan parasitesAssembling the components of the quorum sensing pathway in African trypanosomesThe unconventional kinetoplastid kinetochore: from discovery toward functional understandingRibose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivityAn essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma bruceiQuantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma bruceiCyclin-Dependent Kinase CRK9, Required for Spliced Leader trans Splicing of Pre-mRNA in Trypanosomes, Functions in a Complex with a New L-Type Cyclin and a Kinetoplastid-Specific ProteinIdentification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lambliaNew compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcriptionThe design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome.Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.Efficient Gene Knockdown in Mouse Oocytes through Peptide Nanoparticle-Mediated SiRNA Transfection.Arginine and Lysine Transporters Are Essential for Trypanosoma bruceiGenome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma bruceiSystems analysis of host-parasite interactions.A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes.PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiationA novel protein kinase is essential in bloodstream Trypanosoma bruceiMultiple G-quartet structures in pre-edited mRNAs suggest evolutionary driving force for RNA editing in trypanosomes.Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African TrypanosomeTracking autophagy during proliferation and differentiation of Trypanosoma brucei.Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron.The within-host dynamics of African trypanosome infections.Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.Novel drug discovery for Chagas disease.Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches.Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis.Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri.The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion.RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse.Molecular control of irreversible bistability during trypanosome developmental commitmentExpression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei.Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication.Genetically Validated Drug Targets in Leishmania; Current Knowledge and Future Prospects.
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P2860
Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen
description
2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@ast
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@en
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@nl
type
label
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@ast
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@en
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@nl
prefLabel
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@ast
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@en
Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
@nl
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Regulators of Trypanosoma bruc ...... sing a kinome-wide RNAi screen
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Elaine Brown
Elizabeth B Thomas
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10.1371/JOURNAL.PPAT.1003886
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2014-01-01T00:00:00Z