Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners
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In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.Computational studies to predict or explain G protein coupled receptor polypharmacologyEngagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic painJohn Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y ReceptorsStructure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain.Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine.Safety issues of compounds acting on adenosinergic signalling.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists.Factors influencing biased agonism in recombinant cells expressing the human α1A -adrenoceptor.Polypharmacology of conformationally locked methanocarba nucleosides.
P2860
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P2860
Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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Structural probing of off-targ ...... of adenosine/adenine congeners
@ast
Structural probing of off-targ ...... of adenosine/adenine congeners
@en
Structural probing of off-targ ...... of adenosine/adenine congeners
@nl
type
label
Structural probing of off-targ ...... of adenosine/adenine congeners
@ast
Structural probing of off-targ ...... of adenosine/adenine congeners
@en
Structural probing of off-targ ...... of adenosine/adenine congeners
@nl
prefLabel
Structural probing of off-targ ...... of adenosine/adenine congeners
@ast
Structural probing of off-targ ...... of adenosine/adenine congeners
@en
Structural probing of off-targ ...... of adenosine/adenine congeners
@nl
P2860
P50
P1433
P1476
Structural probing of off-targ ...... of adenosine/adenine congeners
@en
P2093
Daniela Salvemini
P2860
P304
P356
10.1371/JOURNAL.PONE.0097858
P407
P577
2014-01-01T00:00:00Z