TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits
about
Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Medical case reports in the age of genomic medicinePhenome-Wide Association Studies as a Tool to Advance Precision Medicine.Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis CRare variants, autoimmune disease, and arthritisIncreased incidence of rheumatoid arthritis in multiple sclerosis: A nationwide cohort studyBaseline JAK phosphorylation profile of peripheral blood leukocytes, studied by whole blood phosphospecific flow cytometry, is associated with 1-year treatment response in early rheumatoid arthritisProtective alleles and modifier variants in human health and disease.The Alzheimer's Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.Severe viral respiratory infections in children with IFIH1 loss-of-function mutations.Τhe genetics of juvenile idiopathic arthritis: Searching for new susceptibility loci.Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway.The influence of big (clinical) data and genomics on precision medicine and drug development.Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations.Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy.Progress of genome-wide association studies of ankylosing spondylitis.Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records.Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population.Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus.
P2860
Q26767040-A36D1972-C0F8-4A57-B00D-E4830E13EAF2Q26774876-C1F3D8EF-749D-4724-98C1-8D89A41A473CQ33823314-451705E1-0E82-4901-B905-10B210FB3FDFQ33898567-24221536-9BCA-4E68-80FA-DBBE983E0143Q37012282-0C1363F2-6D0F-4FE4-B018-F7C3B4A30FC3Q37077947-889B902E-8C32-45D7-87B8-44F80575795FQ37748066-887D59EF-F3AD-4356-B052-26F0463F8FB0Q38616791-6AFEF580-6C14-48D9-B1B7-D0177A7FB40AQ38696318-CEE49511-0FE1-4730-835C-2803E8E01C2FQ39222478-6A2CC1B9-4D92-48FA-B7A5-AD14BA397D44Q40119340-8E26FB23-DF3C-4858-ADAF-D99E510212A0Q41921778-359ECF71-999A-463E-878E-34CE2C4A7F13Q43254069-950A4506-CD07-42AD-9293-7B9F7A86D68DQ45943634-C305B737-6AD9-455E-B1B2-B470ABD70888Q47105714-11B8BEFD-4C2C-43E2-9FDE-2EFDDAE36C10Q47668330-901DACA6-16B4-4732-AB98-AAC3B33EDD7CQ48302749-A96E25F9-CD8A-4E03-8D6D-BCEEFF0E9D4CQ49871790-747E4B26-D31B-41C9-90F9-2960D16E0279Q49931634-CA98CE9F-1C74-42FE-A4B7-0FE9B2B6A457Q51628046-85BA9EA8-5921-4FEC-B789-64220AD5A182Q52862671-140A95C8-7E94-49B3-A117-9FE89D19568DQ55092221-E5CEEDEC-FD62-4B05-8D2B-C1F8AB7443BA
P2860
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits
description
2015 nî lūn-bûn
@nan
2015 թուականին հրատարակուած գիտական յօդուած
@hyw
2015 թվականին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@ast
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@en
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@nl
type
label
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@ast
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@en
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@nl
prefLabel
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@ast
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@en
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@nl
P2093
P2860
P50
P3181
P1433
P1476
TYK2 protein-coding variants p ...... non-autoimmune complex traits
@en
P2093
Andrew Cagan
Annette Lee
Catrina C Fronick
Corrine Richard-Miceli
David E Larson
Dimitrios A Pappas
Dorothée Diogo
Eli A Stahl
Elizabeth W Karlson
Fina Kurreeman
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0122271
P407
P50
P577
2015-01-01T00:00:00Z