Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis - Test2 - elhamkhani - TriplyDB

Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis

Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis

http://www.wikidata.org/entity/Q28572316

about

Topical cyclosporine A therapy for dry eye syndrome Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL p53 opens the mitochondrial permeability transition pore to trigger necrosis Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state Photoreceptor cell death and rescue in retinal detachment and degenerations Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma.HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT ER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage.Potential therapeutic benefits of strategies directed to mitochondria.Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3 Mitochondrial Ca(2+) influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction Mitochondrial kinase signalling pathways in myocardial protection from ischaemia/reperfusion-induced necrosis.Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.Glutathione and apoptosis.Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.Resveratrol-sensitized UVA induced apoptosis in human keratinocytes through mitochondrial oxidative stress and pore opening Genetic dissection of the permeability transition pore.Sirtuin-3 modulates Bak- and Bax-dependent apoptosis Reactive oxygen species in mitochondria-mediated cell death.Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells.Cyclophilin D is expressed predominantly in mitochondria of gamma-aminobutyric acidergic interneurons.Cell death mechanisms and their implications in toxicology.Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis.Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases.Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria.CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex.Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH.A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes.Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress.Characterization of cyclophilin D in freshwater pearl mussel (Hyriopsis schlegelii).Cyclophilin D ablation is associated with increased end-ischemic mitochondrial hexokinase activity.Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore.

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P2860

Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis

http://www.wikidata.org/entity/Q28572316

description

2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2004

@ast

im Oktober 2004 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2004/10/01)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd op 2004/10/01)

@nl

наукова стаття, опублікована в жовтні 2004

@uk

مقالة علمية (نشرت في أكتوبر 2004)

@ar

name

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@ast

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@en

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@nl

type

label

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@ast

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@en

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@nl

prefLabel

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

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Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@en

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@nl

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P356

P1433

Biochemical Journal

P1476

Cyclophilin-D promotes the mit ...... ects on apoptosis and necrosis

@en

P2093

Martin Crompton

http://www.w3.org/2001/XMLSchema#string

Michela Capano

http://www.w3.org/2001/XMLSchema#string

Mina Edwards

http://www.w3.org/2001/XMLSchema#string

Nicholas Johnson

http://www.w3.org/2001/XMLSchema#string

Yanmin Li

http://www.w3.org/2001/XMLSchema#string

P2860

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms

Cyclophilin catalyzes protein folding in yeast mitochondria.

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

Cytosolic phosphorylation potential

Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization

Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

The mitochondrial permeability transition pore and its role in cell death

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

P304

101–109

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scholarly article

P356

10.1042/BJ20040669

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P407

P433

Pt 1

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P478

383

http://www.w3.org/2001/XMLSchema#string

P577

2004-10-01T00:00:00Z

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P5875

8474374

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P698

15233627

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P921

apoptotic process

P932

1134048

http://www.w3.org/2001/XMLSchema#string