AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
about
Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channelAKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complexM1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-currentKCNQ potassium channels in sensory system and neural circuitsDriving with no brakes: molecular pathophysiology of Kv7 potassium channelsM-current preservation contributes to anticonvulsant effects of valproic acid.Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signalingComplete loss of the cytoplasmic carboxyl terminus of the KCNQ2 potassium channel: a novel mutation in a large Czech pedigree with benign neonatal convulsions or other epileptic phenotypesSignalling scaffolds and local organization of cellular behaviourNetworking with AKAPs: context-dependent regulation of anchored enzymesFocal aggregation of voltage-gated, Kv2.1 subunit-containing, potassium channels at synaptic sites in rat spinal motoneuronesA-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signalingDual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinaseCoordinated signal integration at the M-type potassium channel upon muscarinic stimulationAKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channelsAKAP signalling complexes: focal points in space and timeActivation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway.Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.Analysis and functional implications of phosphorylation of neuronal voltage-gated potassium channels.KCNQ5 channels control resting properties and release probability of a synapseCa2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channelsHomomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation.PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytesChannel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin.Cholesterol inhibits M-type K+ channels via protein kinase C-dependent phosphorylation in sympathetic neurons.Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit.Kv7 channels can function without constitutive calmodulin tetheringATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibitionExpression of a calmodulin-binding KCNQ2 potassium channel fragment modulates neuronal M-current and membrane excitability.Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.Organizing signal transduction through A-kinase anchoring proteins (AKAPs)AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a.Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors.Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complexA change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity
P2860
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P2860
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
description
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juni 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/06/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/06/01)
@nl
наукова стаття, опублікована в червні 2003
@uk
مقالة علمية (نشرت في يونيو 2003)
@ar
name
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@ast
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@en
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@nl
type
label
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@ast
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@en
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@nl
prefLabel
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@ast
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@en
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@nl
P2093
P2860
P50
P356
P1433
P1476
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
@en
P2093
David A Brown
Jia-Sheng Zhang
John D Scott
Lorene K Langeberg
Miho Omaki
Naoto Hoshi
Shigeru Yokoyama
Takahiro Takeuchi
P2860
P2888
P304
P356
10.1038/NN1062
P407
P577
2003-06-01T00:00:00Z