Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses
about
Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granulesFragile X syndrome: loss of local mRNA regulation alters synaptic development and functionA direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome.Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structureA pilot open label, single dose trial of fenobam in adults with fragile X syndrome.The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors.Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neuronsIn Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric DisordersGenetic disruption of voltage-gated calcium channels in psychiatric and neurological disordersThe clinical relevance of neuroplasticity in corticostriatal networks during operant learningMatrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome.Fragile X syndrome and targeted treatment trials.The pathophysiology of fragile X (and what it teaches us about synapses)The FMRP regulon: from targets to disease convergenceFrom Learning to Memory: What Flies Can Tell Us about Intellectual Disability TreatmentChannelopathies and dendritic dysfunction in fragile X syndrome.The unstable repeats--three evolving faces of neurological diseaseDownregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome.Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA GranulesHaploinsufficiency of Cyfip1 produces fragile X-like phenotypes in miceA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Modeling Fragile X Syndrome Using Human Pluripotent Stem CellsKissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAsA new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stabilityIn vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation proteinFragile X mental retardation protein FMRP binds mRNAs in the nucleusFrom mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndromeTDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factorLocalization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neuronsInvolvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expressionRNA and microRNAs in fragile X mental retardationRegulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axonsThe transport of Staufen2-containing ribonucleoprotein complexes involves kinesin motor protein and is modulated by mitogen-activated protein kinase pathwayElongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDExploring the zebra finch Taeniopygia guttata as a novel animal model for the speech-language deficit of fragile X syndromePhosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptorsProgress toward therapeutic potential for AFQ056 in Fragile X syndrome.
P2860
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P2860
Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses
description
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im März 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/03/17)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/03/17)
@nl
наукова стаття, опублікована в березні 2004
@uk
مقالة علمية (نشرت في 17-3-2004)
@ar
name
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@ast
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@en
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@nl
type
label
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@ast
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@en
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@nl
prefLabel
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@ast
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@en
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@nl
P2093
P3181
P1476
Metabotropic glutamate recepto ...... y in dendrites and at synapses
@en
P2093
Gary J Bassell
Jason B Dictenberg
Laura N Antar
Reed C Carroll
Rownak Afroz
P304
P3181
P356
10.1523/JNEUROSCI.0099-04.2004
P407
P577
2004-03-01T00:00:00Z