Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells
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International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyP2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction.P2Y12 receptor expression is a critical determinant of functional responsiveness to ATX's MORFO domainIdentification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12.Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma.P2Ys go neuronal: modulation of Ca2+ and K+ channels by recombinant receptors.Adenine nucleotides inhibit recombinant N-type calcium channels via G protein-coupled mechanisms in HEK 293 cells; involvement of the P2Y13 receptor-type.Pharmacological characterization of nucleotide P2Y receptors on endothelial cells of the mouse aorta.Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors.Purinergic regulation of epithelial transport.Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.Metabotropic P2Y receptors inhibit P2X3 receptor-channels via G protein-dependent facilitation of their desensitization.Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization.The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.Regulation of neuronal ion channels via P2Y receptors.A new angle on blood-CNS interfaces: a role for connexins?Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridinesInto rather unexplored terrain-transcellular transport across the blood-brain barrier.Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain.The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding.N-linked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression.Cerebellar astrocytes co-express several ADP receptors. Presence of functional P2Y(13)-like receptors.G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases.Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networksThe reversible P2Y12 antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.P2Y1 receptors mediate an activation of neuronal calcium-dependent K+ channels.Stimulation of P2X receptors enhances lipooligosaccharide-mediated apoptosis of endothelial cells.P2Y1 receptor inhibits GABA transport through a calcium signalling-dependent mechanism in rat cortical astrocytes.
P2860
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P2860
Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells
description
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im August 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/08/30)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/08/30)
@nl
наукова стаття, опублікована в серпні 2002
@uk
name
Characterization and channel c ...... in capillary endothelial cells
@ast
Characterization and channel c ...... in capillary endothelial cells
@en
Characterization and channel c ...... in capillary endothelial cells
@nl
type
label
Characterization and channel c ...... in capillary endothelial cells
@ast
Characterization and channel c ...... in capillary endothelial cells
@en
Characterization and channel c ...... in capillary endothelial cells
@nl
prefLabel
Characterization and channel c ...... in capillary endothelial cells
@ast
Characterization and channel c ...... in capillary endothelial cells
@en
Characterization and channel c ...... in capillary endothelial cells
@nl
P2093
P2860
P356
P1476
Characterization and channel c ...... in capillary endothelial cells
@en
P2093
Alexander K Filippov
Anton D Michel
Christian Frelin
David A Brown
Eric A Barnard
Joseph Simon
Sara Göransson
P2860
P304
31390-31400
P356
10.1074/JBC.M110714200
P407
P50
P577
2002-06-21T00:00:00Z